INT15407

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Context Info
Confidence 0.62
First Reported 1991
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.69
Pain Relevance 1.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Edn1) extracellular region (Edn1) cell-cell signaling (Edn1)
cytoplasm (Edn1)
Anatomy Link Frequency
plasma 4
Nerve 2
heart 2
Edn1 (Mus musculus)
Pain Link Frequency Relevance Heat
Angina 8 99.50 Very High Very High Very High
Nerve growth factor 8 98.38 Very High Very High Very High
ischemia 6 81.92 Quite High
opioid receptor 12 80.96 Quite High
Pain 2 80.40 Quite High
Opioid 23 74.88 Quite High
diabetic neuropathy 2 74.64 Quite High
adenocard 1 67.16 Quite High
agonist 8 63.80 Quite High
antagonist 14 56.08 Quite High
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 3 99.50 Very High Very High Very High
Hypertension 5 98.84 Very High Very High Very High
Chronic Renal Failure 3 98.34 Very High Very High Very High
Myocardial Infarction 7 97.78 Very High Very High Very High
Diabetes Mellitus 7 84.72 Quite High
Coronary Artery Disease 10 81.92 Quite High
Pain 2 80.40 Quite High
Neuropathic Pain 2 77.80 Quite High
Arrhythmia Under Development 2 76.16 Quite High
Glioma 13 75.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Attenuated CFVR in the symptomatic hypertensive patients was associated with endothelial dysfunction, which results in elevated plasma ET-1 levels.
Positive_regulation (results) of Positive_regulation (elevated) of ET-1 in plasma associated with hypertension
1) Confidence 0.62 Published 2005 Journal Hypertens. Res. Section Abstract Doc Link 16555580 Disease Relevance 0.71 Pain Relevance 0.36
Although plasma ir-ET was composed mainly of big ET and endothelin-1 (ET-1) in normal subjects, that in acute myocardial infarction, chronic renal failure (CRF), essential hypertension, and vasospastic angina pectoris was characterized by an increase of high molecular ir-ET in addition to increases in big ET and ET-1.
Positive_regulation (increase) of Positive_regulation (increases) of ET-1 in plasma associated with angina, chronic renal failure, hypertension and myocardial infarction
2) Confidence 0.42 Published 1991 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 1725426 Disease Relevance 0.66 Pain Relevance 0.10
Nerve growth factor (NGF), which is a potent chemoattractant, is synthesized abundantly by cardiomyocytes and is induced by endothelin-1 upregulation in the heart.
Positive_regulation (induced) of Positive_regulation (upregulation) of endothelin-1 in heart associated with nerve growth factor
3) Confidence 0.24 Published 2008 Journal Curr. Med. Chem. Section Abstract Doc Link 18673222 Disease Relevance 1.21 Pain Relevance 0.40
Nerve growth factor (NGF), a potent chemoattractant, is synthesized abundantly by cardiomyocytes, and is induced by the upregulation of endothelin-1 during development.
Positive_regulation (induced) of Positive_regulation (upregulation) of endothelin-1 in Nerve associated with nerve growth factor
4) Confidence 0.22 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19270423 Disease Relevance 0.98 Pain Relevance 0.40
In the presence of the EGFR, ligand activation of LPA and ET-1 receptors did not increase EGFR phosphorylation even though both the LPA and ET-1 receptors stimulated ERK activity by 10-fold over basal [27].
Neg (not) Positive_regulation (increase) of Positive_regulation (activation) of ET-1
5) Confidence 0.11 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0.13 Pain Relevance 0.23

General Comments

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