INT154081

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Context Info
Confidence 0.16
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.06
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Bad) cell proliferation (Bad) cytosol (Bad)
mitochondrion (Bad) cytoplasm (Bad)
Anatomy Link Frequency
brain 2
Bad (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 43 100.00 Very High Very High Very High
Clonidine 1 99.96 Very High Very High Very High
withdrawal 5 98.56 Very High Very High Very High
tolerance 1 94.16 High High
antagonist 7 92.48 High High
noradrenaline 3 91.40 High High
Hippocampus 1 84.16 Quite High
Cannabinoid 5 75.00 Quite High
monoamine 2 75.00 Quite High
Inflammation 15 71.44 Quite High
Disease Link Frequency Relevance Heat
Repression 3 96.96 Very High Very High Very High
Hypoxia 18 95.64 Very High Very High Very High
Apoptosis 165 92.40 High High
Stress 18 83.48 Quite High
Death 24 79.04 Quite High
INFLAMMATION 18 71.44 Quite High
Dyslipidemia /

Combined Dyslipidemia

3 68.56 Quite High
Cancer 12 60.16 Quite High
Colon Cancer 6 38.56 Quite Low
Infarction 12 13.24 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with reduced Bad translocation to mitochondria, mitochondrial membrane potential is restored and release of cytochrome C and Diablo is suppressed in H2O2-treated cells supplemented with PPAR?
Negative_regulation (reduced) of Localization (translocation) of Bad
1) Confidence 0.16 Published 2010 Journal PPAR Research Section Body Doc Link PMC2938460 Disease Relevance 0.77 Pain Relevance 0.21
upregulation increases Bad sequestration, and, therefore, reduces Bad translocation to mitochondria to interfere with the protective action of Bcl-2, an enhanced Bcl-2 expression should further strengthen the protection of mitochondrial membrane potential and reduction of apoptosis.

9.

Negative_regulation (reduces) of Localization (translocation) of Bad associated with apoptosis
2) Confidence 0.12 Published 2010 Journal PPAR Research Section Body Doc Link PMC2938460 Disease Relevance 0.65 Pain Relevance 0.03
Analysis of subcellular localization of Bad shows reduced Bad translocation to mitochondria and a reciprocal accumulation of Bad in cytosolic fractions of cells treated with PPAR?
Negative_regulation (reduced) of Localization (translocation) of Bad
3) Confidence 0.12 Published 2010 Journal PPAR Research Section Body Doc Link PMC2938460 Disease Relevance 0.58 Pain Relevance 0.08
The inhibitory effect of clonidine (alpha2-agonist; 1 mg/kg) on the accumulation of DOPA (15-41%) and 5-HTP (22-41%) was markedly decreased or abolished after chronic WIN and precipitated withdrawal, mainly in noradrenergic and serotonergic brain regions, which indicated desensitization of alpha2-autoreceptors and alpha2-heteroreceptors regulating the synthesis of noradrenaline and 5-HT.
Negative_regulation (abolished) of Localization (accumulation) of alpha2-agonist in brain associated with noradrenaline, agonist, withdrawal and clonidine
4) Confidence 0.02 Published 2009 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 18709357 Disease Relevance 0 Pain Relevance 0.99

General Comments

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