INT154094

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Context Info
Confidence 0.18
First Reported 2005
Last Reported 2011
Negated 1
Speculated 3
Reported most in Body
Documents 25
Total Number 30
Disease Relevance 30.42
Pain Relevance 7.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 3
corpus callosum 2
microglia 2
lymphocytes 2
spinal cord 1
Eae1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 643 100.00 Very High Very High Very High
Demyelination 230 100.00 Very High Very High Very High
Action potential 89 100.00 Very High Very High Very High
COX-2 inhibitor 35 100.00 Very High Very High Very High
Spinal cord 229 99.88 Very High Very High Very High
Central nervous system 622 99.72 Very High Very High Very High
cytokine 259 99.60 Very High Very High Very High
agonist 145 99.60 Very High Very High Very High
Multiple sclerosis 1341 99.12 Very High Very High Very High
antagonist 53 97.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Multiple Sclerosis 2677 100.00 Very High Very High Very High
Demyelinating Disease 1103 100.00 Very High Very High Very High
Disease 793 100.00 Very High Very High Very High
INFLAMMATION 680 100.00 Very High Very High Very High
Peritonitis 7 100.00 Very High Very High Very High
Recurrence 179 99.32 Very High Very High Very High
Targeted Disruption 167 97.96 Very High Very High Very High
Stress 102 96.84 Very High Very High Very High
Paraplegia 2 96.84 Very High Very High Very High
Sprains And Strains 122 96.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During early EAE (Day 20), both N1 and N2 compound action potential amplitudes were decreased to ?
Negative_regulation (decreased) of EAE associated with action potential and multiple sclerosis
1) Confidence 0.18 Published 2010 Journal Brain Section Body Doc Link PMC2947430 Disease Relevance 0.62 Pain Relevance 0.19
The GST-pi+ mature oligodendrocyte cell population decreased in vehicle-treated EAE compared to normal control corpus callosum.
Negative_regulation (decreased) of EAE in corpus callosum associated with multiple sclerosis
2) Confidence 0.18 Published 2010 Journal Brain Section Body Doc Link PMC2947430 Disease Relevance 0.82 Pain Relevance 0
During chronic EAE, Caspr staining levels were decreased significantly to <60% of normal corpus callosum (Fig. 7B).
Negative_regulation (decreased) of EAE in corpus callosum associated with multiple sclerosis
3) Confidence 0.18 Published 2010 Journal Brain Section Body Doc Link PMC2947430 Disease Relevance 0.93 Pain Relevance 0.46
On average, 40% of axons in the spinal cord were lost in EAE, and serum pNF-H levels were highly correlated with axon loss (r = 0.8, P < 0.001).
Negative_regulation (lost) of EAE in spinal cord associated with multiple sclerosis and spinal cord
4) Confidence 0.16 Published 2008 Journal J. Neurosci. Res. Section Abstract Doc Link 18709652 Disease Relevance 1.95 Pain Relevance 0.30
For example, both CCL2 and CCR2 are expressed in brains of patients with MS [52,53] and deletion of CCR2 leads to an almost complete inhibition of MOG35–55-induced EAE in mice [16].
Negative_regulation (inhibition) of EAE in brains associated with multiple sclerosis
5) Confidence 0.15 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2596102 Disease Relevance 1.10 Pain Relevance 0.37
In the present study, we investigated the effects of Olig1 deficiency on experimental autoimmune encephalomyelitis (EAE), an animal model of MS.
Spec (investigated) Negative_regulation (deficiency) of EAE associated with multiple sclerosis
6) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947525 Disease Relevance 0.75 Pain Relevance 0.33
Here we investigated the effects of Olig1 deficiency on experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS).
Spec (investigated) Negative_regulation (deficiency) of EAE associated with multiple sclerosis
7) Confidence 0.12 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2947525 Disease Relevance 0.96 Pain Relevance 0.13
Since a previous study showed that IL-10 plays a crucial role in the vitamin D3-mediated inhibition of EAE [32], we further assessed the role of IL-10 on the inhibition of IL-17 production by 1,25(OH)2D3 in activated T cells upon stimulation with TGF-?
Negative_regulation (inhibition) of EAE in T cells associated with multiple sclerosis
8) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.10 Pain Relevance 0
The balance between cytokines produced by Th1 and Th2 lymphocytes is considered central to the development of EAE with Th1 cytokines (IFN-?
Negative_regulation (development) of EAE in lymphocytes associated with multiple sclerosis and cytokine
9) Confidence 0.08 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 0.72 Pain Relevance 0.31
However, while the severity of EAE was significantly reduced in oestriol or oestradiol treated mice as compared to placebo treated, treatment with progesterone was indistinguishable from the placebo [129].
Negative_regulation (reduced) of EAE associated with multiple sclerosis
10) Confidence 0.08 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 0.76 Pain Relevance 0
Oestriol treatment has also been shown to be effective in reducing clinical signs in EAE when administered after disease onset [129].
Negative_regulation (reducing) of EAE associated with multiple sclerosis and disease
11) Confidence 0.08 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 1.31 Pain Relevance 0.19
Strikingly, EAE was prevented in a prophylactic treatment regimen of anti-CD40L, and, when EAE was induced in another cohort of animals, CD40L antibody treatment significantly reduced disease severity in an active treatment paradigm [54].
Negative_regulation (prevented) of EAE associated with multiple sclerosis and disease
12) Confidence 0.07 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.70 Pain Relevance 0.11
Within our experimental paradigm, we found that GM-CSF neutralization is selectively effective for the suppression of EAE induced by IL-23–modulated cells (Fig. 5 B).
Negative_regulation (suppression) of EAE associated with multiple sclerosis
13) Confidence 0.07 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442630 Disease Relevance 0.92 Pain Relevance 0.16
These “two-color” mice were examined in three pathological settings: Apoe deficiency on a high-fat diet, thioglycollate induced-peritonitis (localized sterile acute inflammation), and EAE (localized organ-specific autoimmune inflammation).
Spec (examined) Negative_regulation (deficiency) of EAE in fat associated with multiple sclerosis, inflammation and peritonitis
14) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.62 Pain Relevance 0.16
CCR1 antagonist compounds were shown to inhibit CCL3 and CCL5 induced migration of MNCs in a dose dependent manner, and to reduce clinical EAE in rat [36-38].
Negative_regulation (reduce) of EAE associated with multiple sclerosis and antagonist
15) Confidence 0.07 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.44 Pain Relevance 0.37
We observed a statistically significant downregulation of MMP-15, 17 and 25 by microglia in EAE (Fig. 2B, D and 2E) compared to control microglia from unmanipulated mice.
Negative_regulation (downregulation) of EAE in microglia associated with multiple sclerosis
16) Confidence 0.06 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.96 Pain Relevance 0.21
Most strikingly, the two forms of EAE respond differently to specific immunomodulatory interventions; neutralization of either GM-CSF or IL-17 suppressed EAE induced by IL-23–modulated, but not IL-12–modulated, myelin-specific T cells.
Negative_regulation (suppressed) of EAE in T cells associated with multiple sclerosis
17) Confidence 0.05 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442630 Disease Relevance 1.19 Pain Relevance 0.38
did not suppress adoptively transferred EAE, regardless of the polarizing conditions used to generate encephalitogenic cell lines (Fig. 5 D).
Neg (not) Negative_regulation (suppress) of EAE associated with multiple sclerosis
18) Confidence 0.05 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442630 Disease Relevance 0.96 Pain Relevance 0.21
Further studies demonstrated an approximately 50% reduction of clinical EAE activity in the CCR1 (-/-) mice, likely involving the altered migration of monocytes and lymphocytes [34].
Negative_regulation (reduction) of EAE in monocytes associated with multiple sclerosis
19) Confidence 0.05 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.96 Pain Relevance 0.17
In contrast to the observed EAE suppression in the CCR1 (-/-) and CCR2 (-/-) models, the CCR5 knockout mice had the same disease severity as the wild-type controls [35].
Negative_regulation (suppression) of EAE associated with targeted disruption, multiple sclerosis and disease
20) Confidence 0.05 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.98 Pain Relevance 0.22

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