INT154095

Context Info Confidence 0.58 First Reported 2008 Last Reported 2008 Negated 1 Speculated 0 Reported most in Body Documents 6 Total Number 7 Disease Relevance 5.35 Pain Relevance 1.01

mitochondrion (Nefh)

Anatomy Link Frequency parietal cortex 4 blood 2 cerebrospinal fluid 2 dentate gyrus 1 perirhinal cortex 1 Nefh (Mus musculus)

Pain Link Frequency Relevance Heat Multiple sclerosis 12 99.56 Spinal cord 11 93.48 Inflammation 3 91.36 Neuritis 7 84.60 dorsal root ganglion 19 78.96 anesthesia 2 64.24 Eae 12 51.96 Abeta 3 50.00 Sciatic nerve 31 5.00 Hippocampus 24 5.00

Disease Link Frequency Relevance Heat Leber Hereditary Optic Atrophy 96 99.64 Multiple Sclerosis 12 99.56 Demyelinating Disease 10 99.56 Injury 40 99.04 Disease 51 98.08 Pressure And Volume Under Development 12 97.64 INFLAMMATION 3 91.36 Paraplegia 1 90.56 Optic Neuritis 4 84.60 Urological Neuroanatomy 9 81.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Axonal injury was a severe and acute event, insofar as serum pNF-H levels were not significantly elevated at early (EAE day 12) or late (EAE days 35 and 50) disease time points.

Neg (not) Positive_regulation (elevated) of Gene_expression (levels) of pNF-H associated with multiple sclerosis, injury and disease

1) Confidence 0.58 Published 2008 Journal J. Neurosci. Res. Section Abstract Doc Link 18709652 Disease Relevance 1.98 Pain Relevance 0.29

(25–35)-injected mice receiving vehicle compared to control mice, and administration of Kihi-to resulted in significant increases in P-NF-H expression levels in CA1 radiatum, dentate gyrus, parietal cortex, perirhinal cortex and the striatum (Figures 3 and 7).

Positive_regulation (increases) of Gene_expression (expression) of P-NF-H in parietal cortex

2) Confidence 0.24 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.20 Pain Relevance 0.09

During axon regeneration, the developmental pattern of IFs resumes: Vimentin is re-upregulated and expression of mature IFs such as NF-L and NF-H decreases [11]–[15], [17], [27], [32].

Positive_regulation (upregulated) of Gene_expression (expression) of NF-H

3) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.32 Pain Relevance 0.07

(25–35)-injected mice receiving vehicle compared to control mice, and administration of Kihi-to resulted in significant increases in P-NF-H expression levels in CA1 radiatum, dentate gyrus, parietal cortex, perirhinal cortex and the striatum (Figures 3 and 7).

Positive_regulation (increases) of in perirhinal cortex Gene_expression (expression) of P-NF-H in parietal cortex

4) Confidence 0.08 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.20 Pain Relevance 0.09

(25–35)-injected mice receiving vehicle compared to control mice, and administration of Kihi-to resulted in significant increases in P-NF-H expression levels in CA1 radiatum, dentate gyrus, parietal cortex, perirhinal cortex and the striatum (Figures 3 and 7).

Positive_regulation (increases) of in dentate gyrus Gene_expression (expression) of P-NF-H in parietal cortex

5) Confidence 0.08 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.20 Pain Relevance 0.09

In MS, cerebrospinal fluid pNF-H levels increased in those with primary or secondary progressive disease, but in those with relapsing remitting disease pNF-H titers were elevated acutely and decreased later [40].

Positive_regulation (increased) of Gene_expression (levels) of pNF-H in cerebrospinal fluid associated with multiple sclerosis and disease

6) Confidence 0.06 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2605731 Disease Relevance 1.43 Pain Relevance 0.37

Moreover, increased blood levels of pNF-H in some LHON patients suggest not all axons are lost but a number are still undergoing degeneration even many years after visual loss.

Positive_regulation (increased) of Gene_expression (levels) of pNF-H in blood associated with leber hereditary optic atrophy

7) Confidence 0.06 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2605731 Disease Relevance 1.01 Pain Relevance 0

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