INT154095

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Context Info
Confidence 0.58
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 5.35
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nefh)
Anatomy Link Frequency
parietal cortex 4
blood 2
cerebrospinal fluid 2
dentate gyrus 1
perirhinal cortex 1
Nefh (Mus musculus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 12 99.56 Very High Very High Very High
Spinal cord 11 93.48 High High
Inflammation 3 91.36 High High
Neuritis 7 84.60 Quite High
dorsal root ganglion 19 78.96 Quite High
anesthesia 2 64.24 Quite High
Eae 12 51.96 Quite High
Abeta 3 50.00 Quite Low
Sciatic nerve 31 5.00 Very Low Very Low Very Low
Hippocampus 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leber Hereditary Optic Atrophy 96 99.64 Very High Very High Very High
Multiple Sclerosis 12 99.56 Very High Very High Very High
Demyelinating Disease 10 99.56 Very High Very High Very High
Injury 40 99.04 Very High Very High Very High
Disease 51 98.08 Very High Very High Very High
Pressure And Volume Under Development 12 97.64 Very High Very High Very High
INFLAMMATION 3 91.36 High High
Paraplegia 1 90.56 High High
Optic Neuritis 4 84.60 Quite High
Urological Neuroanatomy 9 81.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Axonal injury was a severe and acute event, insofar as serum pNF-H levels were not significantly elevated at early (EAE day 12) or late (EAE days 35 and 50) disease time points.
Neg (not) Positive_regulation (elevated) of Gene_expression (levels) of pNF-H associated with multiple sclerosis, injury and disease
1) Confidence 0.58 Published 2008 Journal J. Neurosci. Res. Section Abstract Doc Link 18709652 Disease Relevance 1.98 Pain Relevance 0.29
(25–35)-injected mice receiving vehicle compared to control mice, and administration of Kihi-to resulted in significant increases in P-NF-H expression levels in CA1 radiatum, dentate gyrus, parietal cortex, perirhinal cortex and the striatum (Figures 3 and 7).
Positive_regulation (increases) of Gene_expression (expression) of P-NF-H in parietal cortex
2) Confidence 0.24 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.20 Pain Relevance 0.09
During axon regeneration, the developmental pattern of IFs resumes: Vimentin is re-upregulated and expression of mature IFs such as NF-L and NF-H decreases [11]–[15], [17], [27], [32].
Positive_regulation (upregulated) of Gene_expression (expression) of NF-H
3) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.32 Pain Relevance 0.07
(25–35)-injected mice receiving vehicle compared to control mice, and administration of Kihi-to resulted in significant increases in P-NF-H expression levels in CA1 radiatum, dentate gyrus, parietal cortex, perirhinal cortex and the striatum (Figures 3 and 7).
Positive_regulation (increases) of in perirhinal cortex Gene_expression (expression) of P-NF-H in parietal cortex
4) Confidence 0.08 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.20 Pain Relevance 0.09
(25–35)-injected mice receiving vehicle compared to control mice, and administration of Kihi-to resulted in significant increases in P-NF-H expression levels in CA1 radiatum, dentate gyrus, parietal cortex, perirhinal cortex and the striatum (Figures 3 and 7).
Positive_regulation (increases) of in dentate gyrus Gene_expression (expression) of P-NF-H in parietal cortex
5) Confidence 0.08 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.20 Pain Relevance 0.09
In MS, cerebrospinal fluid pNF-H levels increased in those with primary or secondary progressive disease, but in those with relapsing remitting disease pNF-H titers were elevated acutely and decreased later [40].
Positive_regulation (increased) of Gene_expression (levels) of pNF-H in cerebrospinal fluid associated with multiple sclerosis and disease
6) Confidence 0.06 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2605731 Disease Relevance 1.43 Pain Relevance 0.37
Moreover, increased blood levels of pNF-H in some LHON patients suggest not all axons are lost but a number are still undergoing degeneration even many years after visual loss.
Positive_regulation (increased) of Gene_expression (levels) of pNF-H in blood associated with leber hereditary optic atrophy
7) Confidence 0.06 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2605731 Disease Relevance 1.01 Pain Relevance 0

General Comments

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