INT154096

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.22
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nefh)
Anatomy Link Frequency
nerves 1
Nefh (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 11 90.16 High High
Inflammation 3 85.00 Quite High
anesthesia 2 76.88 Quite High
Neuritis 1 75.32 Quite High
Multiple sclerosis 2 71.60 Quite High
Eae 4 58.44 Quite High
Abeta 1 50.00 Quite Low
dorsal root ganglion 19 41.12 Quite Low
Sciatic nerve 31 5.00 Very Low Very Low Very Low
Hippocampus 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Sclerosis 12 99.44 Very High Very High Very High
Disease 13 99.16 Very High Very High Very High
Paraplegia 1 97.96 Very High Very High Very High
Injury 30 94.72 High High
Urological Neuroanatomy 3 88.44 High High
Targeted Disruption 3 85.84 High High
INFLAMMATION 3 85.00 Quite High
Neuritis 1 75.32 Quite High
Cognitive Disorder 13 58.44 Quite High
Ganglion Cysts 22 41.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At the time of maximum disease severity (EAE day 22), the average serum pNF-H level reached 5.7 ng/ml, correlating significantly with the EAE paraplegia score (r = 0.75, P < 0.001).
Negative_regulation (reached) of pNF-H associated with paraplegia, multiple sclerosis and disease
1) Confidence 0.41 Published 2008 Journal J. Neurosci. Res. Section Abstract Doc Link 18709652 Disease Relevance 1.92 Pain Relevance 0.29
Expression levels of P-NF-H were decreased in all regions of A?
Negative_regulation (decreased) of P-NF-H
2) Confidence 0.21 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.22 Pain Relevance 0.10
This was demonstrated by a reduction in levels of Vimentin and GAP-43, a marker for axonal regeneration, as well as NF-H, a late marker for axonal maturation in Ndel1 siRNA treated nerves (Fig. 6).
Negative_regulation (reduction) of NF-H in nerves
3) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.09 Pain Relevance 0

General Comments

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