INT154098

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Context Info
Confidence 0.47
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 1.18
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (NTSR1) endoplasmic reticulum (NTSR1) plasma membrane (NTSR1)
signal transducer activity (NTSR1)
Anatomy Link Frequency
neuronal 1
NTSR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 8 99.60 Very High Very High Very High
Calcitonin gene-related peptide 2 94.28 High High
Hyperalgesia 4 92.48 High High
Inflammation 10 89.12 High High
Neuropeptide 7 80.04 Quite High
Inflammatory mediators 1 78.60 Quite High
IPN 2 74.12 Quite High
Morphine 1 72.84 Quite High
agonist 4 51.76 Quite High
Somatostatin 6 44.80 Quite Low
Disease Link Frequency Relevance Heat
Hyperalgesia 4 92.48 High High
INFLAMMATION 8 89.12 High High
Common Cold 16 87.08 High High
Contagious Ecthyma 12 80.88 Quite High
Nociception 2 76.04 Quite High
Hypersensitivity 1 75.00 Quite High
Inflammatory Pain 2 74.12 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 11 35.12 Quite Low
Alzheimer's Dementia 6 27.60 Quite Low
Skin Cancer 1 24.76 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GPR39 might bind a small peptide ligand like the closely related neurotensin receptors NTR1 and 2, which binds a 13-amino-acid peptide derived from a larger precursor protein.
NTR1 Binding (binds) of
1) Confidence 0.47 Published 2002 Journal Genome Biol Section Body Doc Link PMC133447 Disease Relevance 0 Pain Relevance 0.25
Specifically, it has been shown that while deletion of the 3'NTR has only minimal effects on the ability of PV to propagate in HeLa cells, the ability of the virus to propagate in cells of neuronal origin is markedly reduced both in vitro and in vivo [31].
NTR Binding (deletion) of in neuronal
2) Confidence 0.05 Published 2007 Journal Virol J Section Body Doc Link PMC1947962 Disease Relevance 0.08 Pain Relevance 0
Interaction of trans-acting factors with the poliovirus 5'NTR
NTR Binding (Interaction) of
3) Confidence 0.05 Published 2007 Journal Virol J Section Body Doc Link PMC1947962 Disease Relevance 0.09 Pain Relevance 0
Indeed, while their abundance in cells targeted by PV remains to be characterized, a number of cellular proteins have been found to interact with the PV 5'NTR.
NTR Binding (interact) of
4) Confidence 0.05 Published 2007 Journal Virol J Section Body Doc Link PMC1947962 Disease Relevance 0.06 Pain Relevance 0
Experimental techniques employed to identify host cell factors that interact with the PV 5'NTR include: RNA electrophoretic mobility shift assay, UV-mediated crosslinking of proteins to RNA, and biochemical fractionation in junction with supplementation assay.
NTR Binding (interact) of
5) Confidence 0.05 Published 2007 Journal Virol J Section Body Doc Link PMC1947962 Disease Relevance 0.07 Pain Relevance 0
We further demonstrate that pro-NGF is the predominant ligand of p75(NTR) in vivo.
NTR Binding (ligand) of associated with nerve growth factor
6) Confidence 0.01 Published 2008 Journal J. Neurosci. Res. Section Abstract Doc Link 18709654 Disease Relevance 0.88 Pain Relevance 1.04

General Comments

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