INT154104

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Context Info
Confidence 0.39
First Reported 2006
Last Reported 2011
Negated 1
Speculated 3
Reported most in Body
Documents 47
Total Number 50
Disease Relevance 69.82
Pain Relevance 1.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (ARID1B) nucleus (ARID1B) intracellular (ARID1B)
DNA binding (ARID1B)
Anatomy Link Frequency
coronary artery 3
endothelial cells 1
tongue 1
Heart 1
body 1
ARID1B (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 102 99.60 Very High Very High Very High
Inflammation 125 99.48 Very High Very High Very High
tolerance 72 97.16 Very High Very High Very High
alcohol 143 81.20 Quite High
Inflammatory response 17 72.04 Quite High
Neurobehavioral 19 67.52 Quite High
headache 10 62.08 Quite High
depression 21 61.28 Quite High
Pain 2 60.08 Quite High
antagonist 57 48.40 Quite Low
Disease Link Frequency Relevance Heat
Obstructive Sleep Apnea 3097 100.00 Very High Very High Very High
Apnoea 2306 100.00 Very High Very High Very High
Sleep Disorders 960 100.00 Very High Very High Very High
Metabolic Syndrome 821 100.00 Very High Very High Very High
Obesity 732 100.00 Very High Very High Very High
Stroke 322 100.00 Very High Very High Very High
Intellectual Impairment 38 100.00 Very High Very High Very High
Disease 113 99.98 Very High Very High Very High
Hypersomnia 117 99.92 Very High Very High Very High
Cardiovascular Disease 276 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, they examined a metabolic score rather than the presence or not of MS.29 Overall, obesity has already been recognized as a potential confounding factor in the association between MS and OSA, that needs further clarification.20,23–25,29
OSA Binding (association) of associated with apnoea and metabolic syndrome
1) Confidence 0.39 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2868349 Disease Relevance 2.01 Pain Relevance 0
These results provide further evidence for the association between OSA and MS.
OSA Binding (association) of associated with apnoea and metabolic syndrome
2) Confidence 0.39 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2868349 Disease Relevance 1.32 Pain Relevance 0
In conclusion, these results provide further evidence for the association between OSA and MS.
OSA Binding (association) of associated with apnoea and metabolic syndrome
3) Confidence 0.39 Published 2010 Journal Vascular Health and Risk Management Section Abstract Doc Link PMC2868349 Disease Relevance 1.59 Pain Relevance 0
Clearly, the newer IDF criteria offer the opportunity to re-examine the association between MS and OSA.
OSA Spec (examine) Binding (association) of associated with apnoea and metabolic syndrome
4) Confidence 0.39 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2868349 Disease Relevance 0.98 Pain Relevance 0
Previous studies in European and East-Asiatic populations have demonstrated an independent association between OSA and the MS.20,23–25 These studies have used either the National Cholesterol Educational Program – Adult Treatment Program (NCEP-ATP) III criteria or the definition of the International Diabetes Federation (IDF).14,17
OSA Binding (association) of associated with apnoea, diabetes mellitus and metabolic syndrome
5) Confidence 0.39 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2868349 Disease Relevance 2.20 Pain Relevance 0.03
In this specific setting, prevalence of MS was, naturally, high (almost 6 out of 10 patients), and its presence was strongly associated with OSA.
OSA Binding (associated) of associated with apnoea and metabolic syndrome
6) Confidence 0.39 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2868349 Disease Relevance 1.68 Pain Relevance 0
Hyperglycemia was the only component of MS that showed an association with OSA independent of BMI.
OSA Binding (association) of associated with hyperglycemia, apnoea, obesity and metabolic syndrome
7) Confidence 0.39 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2868349 Disease Relevance 2.24 Pain Relevance 0
Therapeutic issues related to gender should be factored into the management of OSA.
OSA Binding (management) of associated with apnoea
8) Confidence 0.31 Published 2008 Journal J Womens Health (Larchmt) Section Abstract Doc Link 18710367 Disease Relevance 1.24 Pain Relevance 0.09
This argument is enhanced by the recent recognition that the risk of OSA needs to be addressed in patients with frank type 2 diabetes, a condition of more profoundly impaired glucose metabolism.37
OSA Binding (risk) of associated with apnoea and diabetes mellitus
9) Confidence 0.30 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2868349 Disease Relevance 1.47 Pain Relevance 0
Therefore, the aim of the present study was to examine the prevalence of MS and its components among OSA patients vs. controls, as well as to investigate which of these components are strongly associated with the presence of OSA in subjects reporting symptoms indicative of sleep-disordered breathing.


OSA Binding (associated) of associated with apnoea and metabolic syndrome
10) Confidence 0.30 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2868349 Disease Relevance 1.91 Pain Relevance 0.06
In this study we found that OSA, a treatable sleep disorder, is associated with more sedentary lifestyles.
OSA Binding (associated) of associated with apnoea and sleep disorders
11) Confidence 0.29 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022211 Disease Relevance 1.20 Pain Relevance 0
Obstructive sleep apnea (OSA) is a common disorder characterized by repetitive episodes of partial or complete obstruction of the upper airway during sleep, ultimately leading to increased respiratory effort, oxyhemoglobin desaturation, sleep fragmentation, and excessive daytime sleepiness.1,2 Several studies have investigated the association of OSA with cardiovascular morbidity and mortality, systemic inflammation and impaired glucose metabolism.2–12
OSA Binding (association) of in respiratory associated with apnoea, inflammation and sleep disorders
12) Confidence 0.29 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2868349 Disease Relevance 1.39 Pain Relevance 0.05
The authors concluded that CPAP is not indicated in non-sleepy patients with significant OSA but long-term studies are required given the association between OSA and cardiovascular disease.


OSA Binding (association) of associated with cardiovascular disease and obstructive sleep apnea
13) Confidence 0.18 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671821 Disease Relevance 1.15 Pain Relevance 0
In view of the increasing evidence of an association between OSA and cardiovascular disease, does CPAP reduce the risk of cardiovascular complications?
OSA Binding (association) of associated with cardiovascular disease and obstructive sleep apnea
14) Confidence 0.18 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671821 Disease Relevance 0.94 Pain Relevance 0
There have been several population-based epidemiological studies which now suggest a direct association between OSA and cardiovascular disease.
OSA Binding (association) of associated with cardiovascular disease and obstructive sleep apnea
15) Confidence 0.18 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671821 Disease Relevance 1.63 Pain Relevance 0
Numerous studies have demonstrated an increased prevalence of OSA at the time of diagnosis of coronary artery disease (Mooe et al 1996; Peker et al 1999) but these studies demonstrate the association between OSA and coronary artery disease at the point of time of a cardiac event rather than in the years leading up to the event when the coronary artery disease was developing.
OSA Binding (association) of in coronary artery associated with coronary artery disease and obstructive sleep apnea
16) Confidence 0.18 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671821 Disease Relevance 1.53 Pain Relevance 0.03
Cross-sectional data from the Sleep Heart Health Study (6424 subjects) also failed to show a significant association between OSA and the prevalence of stroke once corrected for all known cardiovascular risk factors (Shahar et al 2001).
OSA Binding (association) of in Heart associated with stroke and obstructive sleep apnea
17) Confidence 0.18 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671821 Disease Relevance 1.74 Pain Relevance 0
OSA has been known to be associated with cardiovascular disease since the 1970s, including hypertension, myocardial infarction, and cerebrovascular disease, but it was not clear to what degree the relationship was cause and effect or related to confounding factors such as obesity, gender, and age.
OSA Spec (clear) Binding (associated) of associated with cerebrovascular disease, cardiovascular disease, cv unclassified under development, metabolic syndrome, obstructive sleep apnea and myocardial infarction
18) Confidence 0.18 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671821 Disease Relevance 1.75 Pain Relevance 0
OSA is associated with increased reactive oxygen species production in some leukocyte populations and increased adhesion molecules expression and increased monocyte adherence to human endothelial cells in vitro with reductions by treatment with CPAP (Dyugovskaya et al 2002; El-Solh et al 2002).
OSA Binding (associated) of in endothelial cells associated with obstructive sleep apnea and adhesions
19) Confidence 0.18 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671821 Disease Relevance 1.75 Pain Relevance 0.05
In cross-sectional analysis of 1100 subjects, there was a strong association between subjects with mild to moderate OSA with ACE gene deletions and the presence of hypertension.
OSA Binding (association) of associated with cv unclassified under development and obstructive sleep apnea
20) Confidence 0.18 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671821 Disease Relevance 1.38 Pain Relevance 0.04

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