INT154115

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Context Info
Confidence 0.49
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.15
Pain Relevance 6.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PENK) extracellular region (PENK)
Anatomy Link Frequency
spinal nerve 2
neurons 2
PENK (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 18 100.00 Very High Very High Very High
Opioid 10 100.00 Very High Very High Very High
Dynorphin 8 100.00 Very High Very High Very High
electroacupuncture 8 99.96 Very High Very High Very High
Ventral tegmentum 2 99.68 Very High Very High Very High
Acupuncture 72 99.62 Very High Very High Very High
Arthritis 1 99.44 Very High Very High Very High
Serotonin 6 99.00 Very High Very High Very High
Delta opioid receptors 3 99.00 Very High Very High Very High
opioid receptor 13 98.46 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cold Sores 22 99.98 Very High Very High Very High
Herpes Simplex Virus 4 99.84 Very High Very High Very High
Arthritis 1 99.44 Very High Very High Very High
Nociception 13 98.68 Very High Very High Very High
Post Operative Pain 2 97.76 Very High Very High Very High
Ganglion Cysts 24 97.72 Very High Very High Very High
Neuropathic Pain 44 95.76 Very High Very High Very High
INFLAMMATION 18 94.92 High High
Hyperalgesia 21 90.60 High High
Frailty 1 86.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using a mouse model of postoperative pain, we assessed the expression of MOR and delta opioid receptors (DORs) and the efficacy of Herpes Simplex vector-mediated proenkephalin release (SHPE) preventing postoperative nociceptive sensitization induced by remifentanil or surgical incision.
Positive_regulation (mediated) of Localization (release) of proenkephalin associated with nociception, herpes simplex virus, ultiva, delta opioid receptors, opioid receptor and perioperative pain
1) Confidence 0.49 Published 2009 Journal Pain Section Abstract Doc Link 19058913 Disease Relevance 0.68 Pain Relevance 1.16
HSV-mediated release of proenkephalin or the glial cell line-derived neurotrophic factor from DRG neurons provides an analgesic effect in the spinal nerve ligation (SNL) model of neuropathic pain [22,23], and an HSV vector expressing glutamic acid decarboxylase produces gamma-aminobutyric acid to provide an anti-nociceptive effect in the rodent model of chronic spinal cord injury pain [24].
Positive_regulation (mediated) of Localization (release) of proenkephalin in spinal nerve associated with pain, nociception, dorsal root ganglion, spinal cord injury pain, eae, analgesic, neuropathic pain and cold sores
2) Confidence 0.45 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395302 Disease Relevance 2.30 Pain Relevance 1.31
Before the 1990s, most experts agreed on the concept that in normal animal models, lower frequency electroacupuncture (EA) stimulates the release of beta-endorphin, enkephalin and endomorphin, which in turn activates the mu- and delta-opioid receptors, and that higher frequency EA stimulates dynorphin which activates the kappa-opioid receptor.
Positive_regulation (stimulates) of Localization (release) of enkephalin associated with dynorphin, kappa opioid receptor, delta opioid receptors, enkephalin and electroacupuncture
3) Confidence 0.33 Published 2008 Journal Am. J. Chin. Med. Section Abstract Doc Link 18711761 Disease Relevance 0.05 Pain Relevance 1.39
In contrast, 100 Hz electro-acupuncture produced a 2 fold increase in the release of dynorphin but not enkephalin.
Positive_regulation (increase) of Localization (release) of enkephalin associated with dynorphin, enkephalin and acupuncture
4) Confidence 0.18 Published 2007 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1810361 Disease Relevance 0 Pain Relevance 2.06
This causes the release of the opioid peptide met-enkephalin in the ventral tegmental area, which inhibits the activity of neurons that release the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
Positive_regulation (causes) of Localization (release) of enkephalin in neurons associated with ventral tegmentum, gaba, neurotransmitter, enkephalin and opioid
5) Confidence 0.10 Published 2008 Journal Theor Biol Med Model Section Body Doc Link PMC2615745 Disease Relevance 0.11 Pain Relevance 1.01

General Comments

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