INT154134

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.19
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Tymp) cellular_component (Tymp) biological_process (Tymp)
Anatomy Link Frequency
tail 1
intestine 1
Tymp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 48 97.96 Very High Very High Very High
antagonist 2 57.84 Quite High
agonist 5 57.24 Quite High
cva 13 14.24 Low Low
Inflammation 11 5.00 Very Low Very Low Very Low
spastic colon 10 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
unmyelinated 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reperfusion Injury 29 98.72 Very High Very High Very High
Cv General 4 Under Development 23 97.96 Very High Very High Very High
Stress Incontinence 88 85.12 High High
Trematode Infection 1 84.92 Quite High
Cholangiocarcinoma 5 83.40 Quite High
Overactive Bladder 88 83.12 Quite High
Incontinence 50 70.00 Quite High
Increased Venous Pressure Under Development 9 65.52 Quite High
Nicotine Addiction 2 55.24 Quite High
Hypersensitivity 16 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TP-receptors are targets of cyclic GMP-dependent kinase (PKG) which induce desensitization by phosphorylation at Ser331 of the C-tail domain of the receptor [32]–[33].
Regulation (targets) of TP in tail
1) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013104 Disease Relevance 0.07 Pain Relevance 0
The concentrations of TP, ALB and level of IL-10 in intestine in group M decreased significantly while the concentrations of S/L, LDH and the levels of IL-6 and TNF-?
Regulation (concentrations) of TP in intestine
2) Confidence 0.09 Published 2008 Journal BMC Gastroenterol Section Abstract Doc Link PMC2564972 Disease Relevance 0.38 Pain Relevance 0.11
The expression levels of almost all target genes investigated including TP, DPD, ENT1, UNG1, TOP2A, BIRC5, TP73 and DeltaNp73 appeared to be significantly altered in these resistant strains.
Regulation (altered) of TP
3) Confidence 0.01 Published 2008 Journal Chemotherapy Section Body Doc Link 18714155 Disease Relevance 0.25 Pain Relevance 0
The mean values of TP, VLF, LF, and HF in the two groups were not significantly different, but, the mean LF/HF ratio in group B was higher than group A (4.3±3.8 vs. 1.9±1.9, P=0.003) (Table 2).


Regulation (values) of TP
4) Confidence 0.01 Published 2010 Journal International Neurourology Journal Section Body Doc Link PMC3021814 Disease Relevance 0.45 Pain Relevance 0
On frequency domain analysis, the mean values of TP, VLF, LF, and HF in two groups were not significantly different.
Regulation (values) of TP
5) Confidence 0.01 Published 2010 Journal International Neurourology Journal Section Body Doc Link PMC3021814 Disease Relevance 0.06 Pain Relevance 0.06

General Comments

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