INT154137

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Context Info
Confidence 0.18
First Reported 2007
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.82
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Dpyd) oxidoreductase activity (Dpyd) cytoplasm (Dpyd)
Anatomy Link Frequency
urine 1
Dpyd (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Eae 42 94.48 High High
Pain 10 46.24 Quite Low
backache 2 42.56 Quite Low
shoulder pain 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
noradrenaline 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypercalcemia 8 98.88 Very High Very High Very High
Trematode Infection 1 84.76 Quite High
Cholangiocarcinoma 5 83.24 Quite High
Osteoporosis 24 69.56 Quite High
Obesity 2 48.88 Quite Low
Pain 10 46.24 Quite Low
Body Weight 12 43.08 Quite Low
Low Back Pain 2 42.88 Quite Low
Stress 2 31.12 Quite Low
Increased Venous Pressure Under Development 8 12.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The urinary Dpd level directly reflects bone resorption and is a good index for the following reasons: Dpd is released in association with the decomposition of type I collagen during bone resorption; it is not released at the time of bone formation; the Dpd level is not affected by intake of meals; and Dpd is excreted into the urine without being metabolized.
Neg (not) Regulation (affected) of Dpd in urine associated with hypercalcemia
1) Confidence 0.18 Published 2007 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1810356 Disease Relevance 0.41 Pain Relevance 0.03
Change in BMD, Bone area and Urinary Dpd Level (Table 1)
Regulation (Change) of Dpd
2) Confidence 0.18 Published 2007 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1810356 Disease Relevance 0.16 Pain Relevance 0.25
The expression levels of almost all target genes investigated including TP, DPD, ENT1, UNG1, TOP2A, BIRC5, TP73 and DeltaNp73 appeared to be significantly altered in these resistant strains.
Regulation (altered) of DPD
3) Confidence 0.01 Published 2008 Journal Chemotherapy Section Body Doc Link 18714155 Disease Relevance 0.25 Pain Relevance 0

General Comments

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