INT154139

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Context Info
Confidence 0.72
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 4.23
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Top2a) nuclear chromosome (Top2a) aging (Top2a)
chromosome segregation (Top2a) enzyme binding (Top2a) DNA binding (Top2a)
Anatomy Link Frequency
N1-S1 1
hepatocytes 1
Top2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tolerance 6 96.00 Very High Very High Very High
methotrexate 3 92.00 High High
alcohol 6 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 219 99.60 Very High Very High Very High
Aggression 3 98.64 Very High Very High Very High
Cancer 243 98.24 Very High Very High Very High
Apoptosis 24 96.84 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 3 94.32 High High
Recurrence 3 93.48 High High
Pancytopenia 3 93.16 High High
Trematode Infection 1 87.64 High High
Breast Cancer 3 87.32 High High
Cholangiocarcinoma 5 86.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blotting demonstrated abundant TOP2A enzyme expressions in N1-S1 cells using protein extracts from cancer cells and normal Clone 9 hepatocytes (Figure 5a).
Gene_expression (expressions) of TOP2A in hepatocytes associated with cancer
1) Confidence 0.72 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2918526 Disease Relevance 1.44 Pain Relevance 0
Firstly, we found over-expression of TOP2A in N1-S1 HCC both in the protein and the histology levels.
Gene_expression (expression) of TOP2A in N1-S1 associated with hepatocellular cancer
2) Confidence 0.72 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2918526 Disease Relevance 1.14 Pain Relevance 0.06
TOP2A over-expression seems to be correlating with the aggressiveness of HCC in terms of early age onset, advanced histological grading, microvascular invasion, chemoresistence, tumor recurrence and mortality [29,30].
Gene_expression (expression) of TOP2A associated with cancer, hepatocellular cancer, aggression and recurrence
3) Confidence 0.63 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2918526 Disease Relevance 1.38 Pain Relevance 0.13
The expression levels of almost all target genes investigated including TP, DPD, ENT1, UNG1, TOP2A, BIRC5, TP73 and DeltaNp73 appeared to be significantly altered in these resistant strains.
Gene_expression (expression) of TOP2A
4) Confidence 0.12 Published 2008 Journal Chemotherapy Section Body Doc Link 18714155 Disease Relevance 0.26 Pain Relevance 0

General Comments

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