INT154141

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Context Info
Confidence 0.25
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.48
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Top2a) nuclear chromosome (Top2a) aging (Top2a)
chromosome segregation (Top2a) enzyme binding (Top2a) DNA binding (Top2a)
Top2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tolerance 2 84.44 Quite High
methotrexate 1 80.44 Quite High
alcohol 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 73 99.12 Very High Very High Very High
Recurrence 1 96.20 Very High Very High Very High
Cancer 81 95.76 Very High Very High Very High
Aggression 1 91.20 High High
Trematode Infection 1 84.08 Quite High
Advanced Or Metastatic Breast Cancer 1 82.76 Quite High
Cholangiocarcinoma 5 82.56 Quite High
Breast Cancer 1 75.76 Quite High
Solid Tumor 1 74.16 Quite High
Cirrhosis 2 39.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These facts highlight the potential therapeutic value of epirubicin in targeting TOP2A in the management of HCC.
Regulation (targeting) of TOP2A associated with hepatocellular cancer
1) Confidence 0.25 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2918526 Disease Relevance 1.23 Pain Relevance 0.11
The expression levels of almost all target genes investigated including TP, DPD, ENT1, UNG1, TOP2A, BIRC5, TP73 and DeltaNp73 appeared to be significantly altered in these resistant strains.
Regulation (altered) of TOP2A
2) Confidence 0.04 Published 2008 Journal Chemotherapy Section Body Doc Link 18714155 Disease Relevance 0.25 Pain Relevance 0

General Comments

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