INT154143

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Context Info
Confidence 0.25
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.67
Pain Relevance 0

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nuclear chromosome (Birc5) chromosome segregation (Birc5) intracellular (Birc5)
enzyme binding (Birc5) embryo development (Birc5) cytoplasm (Birc5)
Birc5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
palliative 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Trematode Infection 3 87.64 High High
Cholangiocarcinoma 15 86.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: Our study showed that increases in UNG1 and BIRC5 expression and concomitant decreases in TP73 expression may be associated with development of acquired 5-FU resistance in CCA lines and their phenotypes.


Gene_expression (expression) of BIRC5
1) Confidence 0.25 Published 2008 Journal Chemotherapy Section Body Doc Link 18714155 Disease Relevance 0.19 Pain Relevance 0
UNG1 (a DNA repairing enzyme) and BIRC5 (an apoptotic inhibitor) expressions were increased whereas TP73 (a proapoptotic factor) expression levels decreased concomitantly.
Gene_expression (expressions) of BIRC5
2) Confidence 0.25 Published 2008 Journal Chemotherapy Section Body Doc Link 18714155 Disease Relevance 0.22 Pain Relevance 0
The expression levels of almost all target genes investigated including TP, DPD, ENT1, UNG1, TOP2A, BIRC5, TP73 and DeltaNp73 appeared to be significantly altered in these resistant strains.
Gene_expression (expression) of BIRC5
3) Confidence 0.25 Published 2008 Journal Chemotherapy Section Body Doc Link 18714155 Disease Relevance 0.26 Pain Relevance 0

General Comments

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