INT154145

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Context Info
Confidence 0.22
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.41
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (Birc5) chromosome segregation (Birc5) intracellular (Birc5)
enzyme binding (Birc5) embryo development (Birc5) cytoplasm (Birc5)
Birc5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
palliative 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Trematode Infection 2 73.32 Quite High
Cholangiocarcinoma 10 71.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
UNG1 (a DNA repairing enzyme) and BIRC5 (an apoptotic inhibitor) expressions were increased whereas TP73 (a proapoptotic factor) expression levels decreased concomitantly.
Positive_regulation (increased) of Gene_expression (expressions) of BIRC5
1) Confidence 0.22 Published 2008 Journal Chemotherapy Section Body Doc Link 18714155 Disease Relevance 0.22 Pain Relevance 0
CONCLUSION: Our study showed that increases in UNG1 and BIRC5 expression and concomitant decreases in TP73 expression may be associated with development of acquired 5-FU resistance in CCA lines and their phenotypes.


Positive_regulation (increases) of Gene_expression (expression) of BIRC5
2) Confidence 0.16 Published 2008 Journal Chemotherapy Section Body Doc Link 18714155 Disease Relevance 0.19 Pain Relevance 0

General Comments

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