INT154147

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Context Info
Confidence 0.34
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 3.97
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TP73) nucleus (TP73) cell cycle (TP73)
transcription factor binding (TP73) cytoplasm (TP73)
Anatomy Link Frequency
platelet 1
bladder 1
TP73 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 60 83.04 Quite High
adenocard 1 62.84 Quite High
addiction 2 50.00 Quite Low
dexamethasone 9 45.28 Quite Low
Inflammation 75 42.32 Quite Low
chemokine 2 30.04 Quite Low
Kinase C 3 28.08 Quite Low
Arthritis 10 5.00 Very Low Very Low Very Low
antagonist 9 5.00 Very Low Very Low Very Low
Inflammatory mediators 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Transitional Cell Carcinoma 1 99.76 Very High Very High Very High
Cancer 92 99.48 Very High Very High Very High
Bladder Cancer 5 99.24 Very High Very High Very High
Apoptosis 41 97.16 Very High Very High Very High
Neuroblastoma 3 95.00 High High
Skin Cancer 21 93.92 High High
Targeted Disruption 5 91.56 High High
Breast Cancer 14 91.28 High High
Trematode Infection 3 87.64 High High
Cholangiocarcinoma 15 86.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of p73 protein is lower in human bladder cancer tissue compared with adjacent normal tissue in 3 out of 4 pairs as assessed by immunoblot analysis 31.
Gene_expression (expression) of p73 protein in bladder associated with bladder cancer
1) Confidence 0.34 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2938072 Disease Relevance 1.33 Pain Relevance 0.03
The expression levels of almost all target genes investigated including TP, DPD, ENT1, UNG1, TOP2A, BIRC5, TP73 and DeltaNp73 appeared to be significantly altered in these resistant strains.
Gene_expression (expression) of TP73
2) Confidence 0.27 Published 2008 Journal Chemotherapy Section Body Doc Link 18714155 Disease Relevance 0.26 Pain Relevance 0
CONCLUSION: Our study showed that increases in UNG1 and BIRC5 expression and concomitant decreases in TP73 expression may be associated with development of acquired 5-FU resistance in CCA lines and their phenotypes.


Gene_expression (expression) of TP73
3) Confidence 0.27 Published 2008 Journal Chemotherapy Section Body Doc Link 18714155 Disease Relevance 0.19 Pain Relevance 0
Thus there are minimal effects on circulating platelet levels. cMYC binds to and induces expression of (no. 6) p73, and both together downregulate PDGF beta receptors [63].
Gene_expression (expression) of p73 in platelet
4) Confidence 0.27 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958630 Disease Relevance 0.27 Pain Relevance 0.03
For example, p73 expression [43] can be tumor suppressive or oncogenic depending on isoforms of its gene product [44]. p73 expression was downregulated herein by PAR-2 activation, along with 8 fold increases in WWOX, suggesting that PAR-2 leads to reduced p73 transcriptional activity [43].
Gene_expression (expression) of p73 associated with cancer
5) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.73 Pain Relevance 0.07
For example, p73 expression [43] can be tumor suppressive or oncogenic depending on isoforms of its gene product [44]. p73 expression was downregulated herein by PAR-2 activation, along with 8 fold increases in WWOX, suggesting that PAR-2 leads to reduced p73 transcriptional activity [43].
Gene_expression (expression) of p73 associated with cancer
6) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.72 Pain Relevance 0.07
UNG1 (a DNA repairing enzyme) and BIRC5 (an apoptotic inhibitor) expressions were increased whereas TP73 (a proapoptotic factor) expression levels decreased concomitantly.
Gene_expression (expression) of TP73
7) Confidence 0.24 Published 2008 Journal Chemotherapy Section Body Doc Link 18714155 Disease Relevance 0.21 Pain Relevance 0
expression of the p53 family members, p63 and p73, was strongly increased as
Gene_expression (expression) of p73
8) Confidence 0.23 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.26 Pain Relevance 0

General Comments

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