INT154148

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Context Info
Confidence 0.21
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.89
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TP73) nucleus (TP73) cell cycle (TP73)
transcription factor binding (TP73) cytoplasm (TP73)
TP73 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 52 83.04 Quite High
chemokine 2 30.04 Quite Low
Inflammation 70 5.00 Very Low Very Low Very Low
Arthritis 10 5.00 Very Low Very Low Very Low
Inflammatory mediators 8 5.00 Very Low Very Low Very Low
antagonist 8 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
COX2 2 5.00 Very Low Very Low Very Low
spastic colon 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 40 100.00 Very High Very High Very High
Targeted Disruption 4 91.56 High High
Breast Cancer 2 91.28 High High
Carcinoma 2 71.20 Quite High
Trematode Infection 2 70.68 Quite High
Cholangiocarcinoma 10 69.16 Quite High
INFLAMMATION 84 5.00 Very Low Very Low Very Low
Arthritis 10 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low
Metastasis 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: Our study showed that increases in UNG1 and BIRC5 expression and concomitant decreases in TP73 expression may be associated with development of acquired 5-FU resistance in CCA lines and their phenotypes.


Negative_regulation (decreases) of Gene_expression (expression) of TP73
1) Confidence 0.21 Published 2008 Journal Chemotherapy Section Body Doc Link 18714155 Disease Relevance 0.19 Pain Relevance 0
For example, p73 expression [43] can be tumor suppressive or oncogenic depending on isoforms of its gene product [44]. p73 expression was downregulated herein by PAR-2 activation, along with 8 fold increases in WWOX, suggesting that PAR-2 leads to reduced p73 transcriptional activity [43].
Negative_regulation (downregulated) of Gene_expression (expression) of p73 associated with cancer
2) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.74 Pain Relevance 0.07
UNG1 (a DNA repairing enzyme) and BIRC5 (an apoptotic inhibitor) expressions were increased whereas TP73 (a proapoptotic factor) expression levels decreased concomitantly.
Negative_regulation (decreased) of Gene_expression (expression) of TP73
3) Confidence 0.18 Published 2008 Journal Chemotherapy Section Body Doc Link 18714155 Disease Relevance 0.21 Pain Relevance 0
For example, p73 expression [43] can be tumor suppressive or oncogenic depending on isoforms of its gene product [44]. p73 expression was downregulated herein by PAR-2 activation, along with 8 fold increases in WWOX, suggesting that PAR-2 leads to reduced p73 transcriptional activity [43].
Negative_regulation (downregulated) of Gene_expression (expression) of p73 associated with cancer
4) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.76 Pain Relevance 0.07

General Comments

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