INT154149

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Context Info
Confidence 0.18
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.67
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TP73) nucleus (TP73) cell cycle (TP73)
transcription factor binding (TP73) cytoplasm (TP73)
TP73 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 4 44.24 Quite Low
agonist 6 5.00 Very Low Very Low Very Low
COX2 2 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 23 97.16 Very High Very High Very High
Neuroblastoma 3 95.00 High High
Trematode Infection 2 71.40 Quite High
Stress 8 70.16 Quite High
Cholangiocarcinoma 10 69.88 Quite High
INFLAMMATION 5 44.24 Quite Low
Cancer 10 34.88 Quite Low
Colon Cancer 5 5.00 Very Low Very Low Very Low
Repression 2 5.00 Very Low Very Low Very Low
Lymphatic System Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
expression of the p53 family members, p63 and p73, was strongly increased as
Positive_regulation (increased) of Gene_expression (expression) of p73
1) Confidence 0.18 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.26 Pain Relevance 0
CONCLUSION: Our study showed that increases in UNG1 and BIRC5 expression and concomitant decreases in TP73 expression may be associated with development of acquired 5-FU resistance in CCA lines and their phenotypes.


Positive_regulation (increases) of Gene_expression (expression) of TP73
2) Confidence 0.16 Published 2008 Journal Chemotherapy Section Body Doc Link 18714155 Disease Relevance 0.19 Pain Relevance 0
UNG1 (a DNA repairing enzyme) and BIRC5 (an apoptotic inhibitor) expressions were increased whereas TP73 (a proapoptotic factor) expression levels decreased concomitantly.
Positive_regulation (increased) of Gene_expression (expression) of TP73
3) Confidence 0.15 Published 2008 Journal Chemotherapy Section Body Doc Link 18714155 Disease Relevance 0.21 Pain Relevance 0

General Comments

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