INT154150

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Context Info
Confidence 0.15
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.81
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TP73) nucleus (TP73) cell cycle (TP73)
transcription factor binding (TP73) cytoplasm (TP73)
TP73 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 52 96.44 Very High Very High Very High
medulla 1 91.48 High High
withdrawal 2 86.24 High High
Nerve growth factor 1 85.76 High High
adenocard 1 68.44 Quite High
cytokine 11 13.60 Low Low
Inflammation 27 11.72 Low Low
cINOD 18 5.00 Very Low Very Low Very Low
dexamethasone 8 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 26 99.76 Very High Very High Very High
Neuroblastoma 2 99.00 Very High Very High Very High
Bladder Cancer 6 97.04 Very High Very High Very High
Transitional Cell Carcinoma 2 96.36 Very High Very High Very High
Apoptosis 167 92.52 High High
Pheochromocytoma 1 90.40 High High
Cancer 166 84.08 Quite High
Fever 41 83.52 Quite High
Trematode Infection 1 83.52 Quite High
Cholangiocarcinoma 5 82.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, celecoxib was shown to able to modulate different isoforms of p73, a p53 family member in neuroblastoma cell lines [109]. p73 encodes many isoforms with different roles.
Regulation (modulate) of p73 associated with neuroblastoma
1) Confidence 0.15 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.34 Pain Relevance 0.21
We have shown in vitro in SCC cells that p73 is important in calcitriol antiproliferative effect; we are also examining p73 status in vivo in human transitional cell carcinoma.
Regulation (important) of p73 associated with skin cancer and transitional cell carcinoma
2) Confidence 0.12 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2938072 Disease Relevance 1.22 Pain Relevance 0.03
The expression levels of almost all target genes investigated including TP, DPD, ENT1, UNG1, TOP2A, BIRC5, TP73 and DeltaNp73 appeared to be significantly altered in these resistant strains.
Regulation (altered) of TP73
3) Confidence 0.10 Published 2008 Journal Chemotherapy Section Body Doc Link 18714155 Disease Relevance 0.25 Pain Relevance 0

General Comments

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