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Context Info
Confidence 0.67
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 5.71
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TP73) nucleus (TP73) cell cycle (TP73)
transcription factor binding (TP73) cytoplasm (TP73)
Anatomy Link Frequency
bladder 1
TP73 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 52 95.28 Very High Very High Very High
Inflammation 63 93.96 High High
COX2 1 83.52 Quite High
medulla 1 68.60 Quite High
withdrawal 2 63.36 Quite High
Nerve growth factor 1 62.88 Quite High
adenocard 2 55.92 Quite High
agonist 28 16.64 Low Low
antagonist 9 15.60 Low Low
cINOD 19 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 226 99.28 Very High Very High Very High
Bladder Cancer 11 99.04 Very High Very High Very High
Neuroblastoma 2 96.44 Very High Very High Very High
Skin Cancer 47 96.40 Very High Very High Very High
INFLAMMATION 72 93.96 High High
Apoptosis 183 93.16 High High
Transitional Cell Carcinoma 3 92.84 High High
Breast Cancer 28 89.20 High High
Disease 11 88.20 High High
Leukemia 27 79.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been shown that celecoxib was able to upregulate Tap73 and downregulate DeltaNp73.
Positive_regulation (upregulate) of p73
1) Confidence 0.67 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.32 Pain Relevance 0.26
Further study shows that calcitriol increased the protein level of p73, a p53 family member, which contributed to calcitriol and cisplatin-mediated growth inhibition in SCC cells 19.
Positive_regulation (increased) of p73 associated with skin cancer
2) Confidence 0.30 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2938072 Disease Relevance 1.66 Pain Relevance 0
Calcitriol augments p73 protein level in T24 and UMUC3 bladder cancer cells, which may contribute to this growth inhibition 31.
Positive_regulation (augments) of p73 protein in bladder associated with bladder cancer
3) Confidence 0.30 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2938072 Disease Relevance 1.34 Pain Relevance 0.03
UNG1 (a DNA repairing enzyme) and BIRC5 (an apoptotic inhibitor) expressions were increased whereas TP73 (a proapoptotic factor) expression levels decreased concomitantly.
Positive_regulation (increased) of TP73
4) Confidence 0.15 Published 2008 Journal Chemotherapy Section Body Doc Link 18714155 Disease Relevance 0.21 Pain Relevance 0
Tumour and growth factor genes like WWOX, p73, ITGB4 and AREG were strongly up-regulated by PAR2 activation, supporting roles for PAR2 in proliferation, tumour growth and, perhaps surprisingly, also tumour suppression.
Positive_regulation (regulated) of p73 associated with cancer
5) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 1.18 Pain Relevance 0.24

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