INT154175

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Context Info
Confidence 0.62
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.48
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (SYK) cytosol (SYK) plasma membrane (SYK)
cytoplasm (SYK)
Anatomy Link Frequency
mast cell 1
SYK (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 15 99.08 Very High Very High Very High
cytokine 14 80.24 Quite High
antagonist 4 76.24 Quite High
chemokine 1 72.08 Quite High
pruritus 1 57.60 Quite High
headache 1 54.88 Quite High
Pain 1 53.28 Quite High
Onset of action 1 47.60 Quite Low
Angina 1 45.00 Quite Low
corticosteroid 6 15.76 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 14 99.08 Very High Very High Very High
Hypersensitivity 28 98.56 Very High Very High Very High
Increased Venous Pressure Under Development 1 98.20 Very High Very High Very High
Asthma 50 93.76 High High
Thrombosis 2 92.72 High High
Stress 6 75.00 Quite High
Adhesions 2 65.40 Quite High
Rhinitis 9 64.80 Quite High
Sneezing 1 59.76 Quite High
Pruritus 1 57.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pharmacological regulation of Syk may prove efficacious in treating occlusive vascular disease.
Regulation (regulation) of Syk associated with increased venous pressure under development
1) Confidence 0.62 Published 2008 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 18715989 Disease Relevance 0.44 Pain Relevance 0
One target in the mast cell that is critical for degranulation is Syk kinase.
Regulation (target) of Syk kinase in mast cell
2) Confidence 0.03 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946700 Disease Relevance 1.04 Pain Relevance 0.34

General Comments

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