INT154177

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 2
Disease Relevance 1.51
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (SYK) cytosol (SYK) plasma membrane (SYK)
cytoplasm (SYK)
Anatomy Link Frequency
blood 2
Platelets 2
SYK (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 2 86.12 High High
Disease Link Frequency Relevance Heat
Stress 12 97.52 Very High Very High Very High
Atherosclerotic Plaque 2 97.20 Very High Very High Very High
Thrombosis 4 96.88 Very High Very High Very High
Myocardial Infarction 2 87.28 High High
Cv General 3 Under Development 2 86.12 High High
Stroke 2 85.28 High High
Increased Venous Pressure Under Development 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with Syk inhibitors not only reduced SIPA and Syk phosphorylation in isolated platelets, but also diminished, up to 50%, the platelet-mediated thrombus formation when whole blood was perfused over type-III collagen.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of Syk in blood associated with thrombosis
1) Confidence 0.43 Published 2008 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 18715989 Disease Relevance 0.66 Pain Relevance 0.06
Platelets undergo phosphorylation of Syk at Y525/526 and Y352 in response to pathophysiological shear stress.
Negative_regulation (undergo) of Phosphorylation (phosphorylation) of Syk in Platelets associated with stress
2) Confidence 0.37 Published 2008 Journal Am. J. Physiol., Cell Physiol. Section Title Doc Link 18715989 Disease Relevance 0.85 Pain Relevance 0.09

General Comments

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