INT154180

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 4.67
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (SYK) cytosol (SYK) plasma membrane (SYK)
cytoplasm (SYK)
Anatomy Link Frequency
spleen 2
blood 1
SYK (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 2 96.56 Very High Very High Very High
Arthritis 2 95.60 Very High Very High Very High
tolerance 2 79.04 Quite High
Angina 2 74.56 Quite High
Rheumatism 2 40.88 Quite Low
abatacept 2 34.52 Quite Low
rheumatoid arthritis 8 24.96 Low Low
methotrexate 32 5.00 Very Low Very Low Very Low
Infliximab 12 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Vasculitis 120 99.92 Very High Very High Very High
Disease 84 97.40 Very High Very High Very High
Stress 12 96.96 Very High Very High Very High
Low Back Pain 2 96.56 Very High Very High Very High
Seronegative Spondarthritis 2 95.60 Very High Very High Very High
Nephritis 2 95.40 Very High Very High Very High
Thrombosis 4 95.04 Very High Very High Very High
Uveitis 2 94.76 High High
Glomerulonephritis 20 91.24 High High
Urological Neuroanatomy 34 87.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased phosphorylation at both sites was attenuated by pharmacological inhibition of Syk using two different Syk inhibitors, piceatannol and 3-(1-methyl-1H-indol-3-yl-methylene)-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide (OXSI-2), and by inhibition of upstream Src-family kinases (SFKs).
Negative_regulation (inhibition) of Syk
1) Confidence 0.43 Published 2008 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 18715989 Disease Relevance 0.82 Pain Relevance 0.07
Pretreatment with Syk inhibitors not only reduced SIPA and Syk phosphorylation in isolated platelets, but also diminished, up to 50%, the platelet-mediated thrombus formation when whole blood was perfused over type-III collagen.
Negative_regulation (inhibitors) of Syk in blood associated with thrombosis
2) Confidence 0.43 Published 2008 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 18715989 Disease Relevance 0.67 Pain Relevance 0.06
Inhibition of spleen tyrosine kinase (Syk) has been trialed in rheumatoid arthritis95 and has been shown in our laboratory to prevent and treat nephrotoxic nephritis in rats.96 Syk inhibition might be an important therapeutic target in AAV.
Negative_regulation (Inhibition) of Syk in spleen associated with nephritis and vasculitis
3) Confidence 0.17 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2893757 Disease Relevance 1.59 Pain Relevance 0.18
Inhibition of spleen tyrosine kinase (Syk) has been trialed in rheumatoid arthritis95 and has been shown in our laboratory to prevent and treat nephrotoxic nephritis in rats.96 Syk inhibition might be an important therapeutic target in AAV.
Negative_regulation (Inhibition) of spleen tyrosine kinase in spleen associated with nephritis and vasculitis
4) Confidence 0.17 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2893757 Disease Relevance 1.59 Pain Relevance 0.18

General Comments

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