INT154182

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Context Info
Confidence 0.82
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 5.54
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (SYK) cytosol (SYK) plasma membrane (SYK)
cytoplasm (SYK)
Anatomy Link Frequency
blood 1
Platelets 1
SYK (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 4 94.76 High High
chemokine 15 75.16 Quite High
Arthritis 1 9.80 Low Low
corticosteroid 15 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Antihistamine 4 5.00 Very Low Very Low Very Low
Spinal cord 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 24 98.36 Very High Very High Very High
Atherosclerotic Plaque 4 97.20 Very High Very High Very High
Thrombosis 9 96.88 Very High Very High Very High
Stroke 4 95.24 Very High Very High Very High
Cv General 3 Under Development 4 94.76 High High
Myocardial Infarction 4 94.08 High High
T-cell Lymphoma 63 79.92 Quite High
Cancer 125 78.08 Quite High
Lymphatic System Cancer 366 76.40 Quite High
Apoptosis 16 74.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With the use of phospho-Syk specific antibodies, these data are the first to show that key regulatory sites of Syk at tyrosines 525/526 (Y525/526) and tyrosine 352 (Y352) were phosphorylated in response to pathophysiological shear stress.
Phosphorylation (phosphorylated) of Syk associated with stress
1) Confidence 0.82 Published 2008 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 18715989 Disease Relevance 0.83 Pain Relevance 0.08
Pretreatment with Syk inhibitors not only reduced SIPA and Syk phosphorylation in isolated platelets, but also diminished, up to 50%, the platelet-mediated thrombus formation when whole blood was perfused over type-III collagen.
Phosphorylation (phosphorylation) of Syk in blood associated with thrombosis
2) Confidence 0.82 Published 2008 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 18715989 Disease Relevance 0.66 Pain Relevance 0.06
The extent of Syk tyrosine phosphorylation induced by pathophysiological levels of shear stress (100 dyn/cm(2)) was significantly greater than that resulting from physiological shear stress (10 dyn/cm(2)).
Phosphorylation (phosphorylation) of Syk associated with stress
3) Confidence 0.82 Published 2008 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 18715989 Disease Relevance 0.88 Pain Relevance 0.09
Platelets undergo phosphorylation of Syk at Y525/526 and Y352 in response to pathophysiological shear stress.
Phosphorylation (phosphorylation) of Syk in Platelets associated with stress
4) Confidence 0.72 Published 2008 Journal Am. J. Physiol., Cell Physiol. Section Title Doc Link 18715989 Disease Relevance 0.85 Pain Relevance 0.09
SHP-1 is a tyrosine phosphatase that negatively regulates several intracellular signaling pathways, including the calcium pathway, through dephosphorylation of signaling intermediates, such as Lyn and Syk.
Phosphorylation (dephosphorylation) of Syk
5) Confidence 0.32 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526638 Disease Relevance 0.29 Pain Relevance 0
Additionally, Western blot demonstrated that Syk-positive PTCLs show tyrosine (525/526) phosphorylation, which is known to be required for Syk activation.
Phosphorylation (phosphorylation) of Syk
6) Confidence 0.26 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.77 Pain Relevance 0.04
Overexpression of Syk, phosphorylation of its Y525/526 residues, and the availability of orally available Syk inhibitors suggest that Syk merits further evaluation as a candidate target for pharmacologic PTK inhibition in patients with PTCL [16].
Phosphorylation (phosphorylation) of Syk
7) Confidence 0.26 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.62 Pain Relevance 0.03
Overexpression of Syk, phosphorylation of its Y525/526 residues, and the availability of orally available Syk inhibitors suggest that Syk merits further evaluation as a candidate target for pharmacologic PTK inhibition in patients with PTCL [16].
Phosphorylation (phosphorylation) of Syk
8) Confidence 0.20 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.64 Pain Relevance 0.03

General Comments

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