INT154187

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 3.07
Pain Relevance 2.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Il6, Cd2) extracellular space (Il6) aging (Il6)
protein complex (Cd2)
Anatomy Link Frequency
neurons 3
microglia 1
Il6 (Rattus norvegicus)
Cd2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Eae 18 99.20 Very High Very High Very High
Spinal cord 2 98.40 Very High Very High Very High
Sciatic nerve 10 97.60 Very High Very High Very High
Dorsal horn 4 96.60 Very High Very High Very High
Pain 4 95.96 Very High Very High Very High
intrathecal 2 95.64 Very High Very High Very High
cytokine 8 94.28 High High
fifth nerve 4 90.32 High High
Neuropathic pain 6 75.00 Quite High
neuralgia 4 25.00 Low Low
Disease Link Frequency Relevance Heat
Injury 28 100.00 Very High Very High Very High
Pain 4 95.96 Very High Very High Very High
Neuropathic Pain 6 75.00 Quite High
Ganglion Cysts 2 73.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We show that IL-6 can upregulate OX-42 and ATF3 expression in cultured microglia and neurons from spinal cord, respectively, as well as in the dorsal horn after acute intrathecal administration of the cytokine.
IL-6 Positive_regulation (upregulate) of Gene_expression (expression) of OX-42 in neurons associated with injury, dorsal horn, cytokine, intrathecal and spinal cord
1) Confidence 0.08 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18716207 Disease Relevance 1.53 Pain Relevance 1.35
We show that IL-6 can upregulate OX-42 and ATF3 expression in cultured microglia and neurons from spinal cord, respectively, as well as in the dorsal horn after acute intrathecal administration of the cytokine.
IL-6 Positive_regulation (upregulate) of in microglia Gene_expression (expression) of OX-42 in neurons associated with injury, dorsal horn, cytokine, intrathecal and spinal cord
2) Confidence 0.03 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18716207 Disease Relevance 1.53 Pain Relevance 1.35

General Comments

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