INT154190

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Context Info
Confidence 0.31
First Reported 2008
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.31
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Mtap2) intracellular (Mtap2) protein complex (Mtap2)
cytoplasm (Mtap2)
Anatomy Link Frequency
dendrites 1
neuronal 1
neuropil 1
Mtap2 (Mus musculus)
Pain Link Frequency Relevance Heat
Substantia nigra 18 100.00 Very High Very High Very High
Neurotransmitter 1 88.08 High High
Pain 1 76.60 Quite High
anesthesia 6 76.36 Quite High
ischemia 1 75.56 Quite High
imagery 5 63.88 Quite High
Dopamine 18 50.00 Quite Low
Central nervous system 15 44.40 Quite Low
midbrain 3 22.08 Low Low
tetrodotoxin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 25 98.32 Very High Very High Very High
Pain 1 76.60 Quite High
Cv Unclassified Under Development 1 75.56 Quite High
Parkinson's Disease 15 42.80 Quite Low
Hypersensitivity 10 5.00 Very Low Very Low Very Low
Infection 4 5.00 Very Low Very Low Very Low
Adhesions 3 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 3 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This effect relies on Mtap2 binding to microtubules.
Mtap2 Binding (binding) of
1) Confidence 0.31 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18716213 Disease Relevance 0.15 Pain Relevance 0.23
We studied the cellular localization of the hCAR protein in the transgenic animals in more detail using dual-label immunohistochemistry. hCAR was not seen to localize with the astrocyte marker ALDHL1 in the SN (Figure S1 A, B), nor with the neuronal marker MAP2 in the cortex, SN or STR (Figure S1 C–H).
MAP2 Neg (nor) Binding (localize) of in neuronal associated with targeted disruption and substantia nigra
2) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.16 Pain Relevance 0.20
A punctuate pattern of MHCI-HC immunoreactivity that colocalized with MAP2-positive neuronal processes was observed in the neuronal somata, dendrites and neuropil in the main thalamorecipient layer of V1, layer IV (Figure 5).
MAP2 Binding (colocalized) of in dendrites
3) Confidence 0.10 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0
A punctuate pattern of MHCI-HC immunoreactivity that colocalized with MAP2-positive neuronal processes was observed in the neuronal somata, dendrites and neuropil in the main thalamorecipient layer of V1, layer IV (Figure 5).
MAP2 Binding (colocalized) of in neuropil
4) Confidence 0.03 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0

General Comments

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