INT154193

Context Info Confidence 0.22 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 3 Disease Relevance 0.48 Pain Relevance 0.74

cytoskeleton (Mtap2) intracellular (Mtap2) plasma membrane (KCNK2) protein complex (Mtap2) cytoplasm (Mtap2)

KCNK2 (Homo sapiens) Mtap2 (Mus musculus)

Pain Link Frequency Relevance Heat Neurotransmitter 3 94.56 Pain 3 83.08 anesthesia 3 82.84 ischemia 3 82.04

Disease Link Frequency Relevance Heat Pain 3 83.08 Cv Unclassified Under Development 3 82.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Mtap2 binding to TREK-1 and TREK-2 does not affect directly channel properties but enhances channel surface expression and current density.

TREK-1 Binding (binding) of Mtap2

1) Confidence 0.22 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18716213 Disease Relevance 0.17 Pain Relevance 0.25

Mtap2 binding to TREK-1 and TREK-2 does not affect directly channel properties but enhances channel surface expression and current density.

TREK-2 Binding (binding) of Mtap2

2) Confidence 0.22 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18716213 Disease Relevance 0.17 Pain Relevance 0.25

Mtap2 and AKAP150 interacting sites in TREK-1 are distinct and both proteins can dock simultaneously.

TREK-1 Binding (interacting) of Mtap2

3) Confidence 0.17 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18716213 Disease Relevance 0.15 Pain Relevance 0.23

General Comments

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