INT154197

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Context Info
Confidence 0.44
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.32
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Prkg1) Golgi apparatus (Prkg1) plasma membrane (Prkg1)
kinase activity (Prkg1) cytoplasm (Prkg1)
Anatomy Link Frequency
spinal 1
Prkg1 (Mus musculus)
Pain Link Frequency Relevance Heat
intrathecal 1 90.88 High High
Pain 6 89.40 High High
central sensitization 2 88.72 High High
Acute pain 1 86.88 High High
Neuropathic pain 4 85.48 High High
Inflammation 12 85.04 High High
Dorsal horn 1 77.60 Quite High
ketamine 2 76.24 Quite High
ischemia 20 72.40 Quite High
Spinal cord 1 69.84 Quite High
Disease Link Frequency Relevance Heat
Natriuresis 3 99.84 Very High Very High Very High
Nociception 3 97.38 Very High Very High Very High
Pain 4 89.40 High High
Neuropathic Pain 4 85.48 High High
INFLAMMATION 10 84.68 Quite High
Pressure And Volume Under Development 4 73.64 Quite High
Cv Unclassified Under Development 20 72.40 Quite High
Pulmonary Hypertension 2 66.28 Quite High
Apoptosis 8 59.80 Quite High
Increased Venous Pressure Under Development 4 41.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Surprisingly, during spinal nociceptive processing, cGMP produced by NO-GC may activate signaling pathways different from cGMP-dependent protein kinase I (cGKI), whereas cGKI can be activated by natriuretic peptide receptor-B dependent cGMP production.
Positive_regulation (activated) of cGKI in spinal associated with natriuresis and nociception
1) Confidence 0.44 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18716216 Disease Relevance 1.04 Pain Relevance 0.99
LZM mice harbor a discrete mutation in cGKI?
Positive_regulation (mutation) of cGKI
2) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2654072 Disease Relevance 0.14 Pain Relevance 0.14
LZM knockin mice harbor a mutation that disrupts the leucine zipper domain required for cGKI?
Positive_regulation (required) of cGKI
3) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2654072 Disease Relevance 0.13 Pain Relevance 0

General Comments

This test has worked.

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