INT154198

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Context Info
Confidence 0.48
First Reported 2008
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 9
Total Number 23
Disease Relevance 6.91
Pain Relevance 3.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pick1) protein targeting (Pick1) Golgi apparatus (Pick1)
ATPase activity (Pick1) plasma membrane (Pick1) enzyme binding (Pick1)
Anatomy Link Frequency
cerebellar granule cell 1
Pick1 (Mus musculus)
Pain Link Frequency Relevance Heat
ASIC 165 99.76 Very High Very High Very High
Kinase C 38 99.48 Very High Very High Very High
Neurotransmitter 10 99.28 Very High Very High Very High
agonist 11 97.92 Very High Very High Very High
Glutamate 30 97.60 Very High Very High Very High
Glutamate receptor 32 95.36 Very High Very High Very High
Hippocampus 15 93.36 High High
depression 6 93.36 High High
Dopamine 34 90.72 High High
Pain 31 90.40 High High
Disease Link Frequency Relevance Heat
Cancer 5 100.00 Very High Very High Very High
Toxicity 90 99.92 Very High Very High Very High
Targeted Disruption 35 93.44 High High
Depression 6 93.36 High High
Disease 63 91.48 High High
Anxiety Disorder 20 91.40 High High
Pain 29 90.40 High High
Brain Injury 15 89.76 High High
Acidosis 60 89.04 High High
Convulsion 15 88.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunoprecipitation showed that the PICK1-mGluR7a interaction is disrupted in mGluR7a(AAA/AAA) mice.
PICK1 Binding (interaction) of
1) Confidence 0.48 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18716219 Disease Relevance 0.39 Pain Relevance 0.27
PICK1-regulated surface expression of ASIC1a is dependent on the lipid binding of PICK1's BAR domain
PICK1 Binding (binding) of
2) Confidence 0.42 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0.04
The BAR domain of PICK1 binds to lipids and this lipid binding regulates surface expression of AMPA receptors [36].
PICK1 Binding (binds) of
3) Confidence 0.42 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0.04
Next, we asked whether lipid binding of PICK1 affects ASIC1a subcellular localization.
PICK1 Spec (whether) Binding (binding) of
4) Confidence 0.42 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0.03
In addition, and similar to our earlier studies on AMPA receptors [36], the effect of PICK1 on ASIC1a localization and surface also requires the lipid binding of PICK1.
PICK1 Binding (binding) of
5) Confidence 0.42 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.48 Pain Relevance 0.08
Of note, the major lipid molecules that bind to PICK1 are phosphoinositides, which are dynamically modified by lipid kinase and phosphatase on the cell membrane [36].
PICK1 Binding (bind) of
6) Confidence 0.42 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.16 Pain Relevance 0.08
In cerebellar granule cell cultures, the group III mGluR agonist l-AP-4 decreased the frequency of spontaneous excitatory currents in neurons derived from wild-type but not mGluR7a(AAA/AAA) mice, consistent with the interaction between mGluR7a and PICK1 being required for protein kinase C-mediated inhibition of glutamate release.
PICK1 Binding (interaction) of in cerebellar granule cell associated with glutamate, kinase c and agonist
7) Confidence 0.37 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18716219 Disease Relevance 0.48 Pain Relevance 0.40
Together, these results indicate that PICK1 binding to the C-terminal region of mGluR7a is crucial for agonist-triggered presynaptic signaling in vivo.
PICK1 Binding (binding) of associated with agonist
8) Confidence 0.36 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18716219 Disease Relevance 0.39 Pain Relevance 0.35
Protein interacting with C kinase 1 (PICK1), a postsynaptic density protein-95/disc-large tumor suppressor protein/zonula occludens-1 (PDZ)-domain protein, binds to the three C-terminal amino acids (-LVI) of the predominant mGluR7 splice variant, mGluR7a, and has been implicated in the synaptic clustering of this receptor.
PICK1 Binding (binds) of associated with cancer
9) Confidence 0.36 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18716219 Disease Relevance 0.32 Pain Relevance 0.16
Protein interacting with C kinase 1 (PICK1), a postsynaptic density protein-95/disc-large tumor suppressor protein/zonula occludens-1 (PDZ)-domain protein, binds to the three C-terminal amino acids (-LVI) of the predominant mGluR7 splice variant, mGluR7a, and has been implicated in the synaptic clustering of this receptor.
PICK1 Binding (interacting) of associated with cancer
10) Confidence 0.36 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18716219 Disease Relevance 0.25 Pain Relevance 0.13
PICK1 regulates ASIC1a-mediated acidotoxicity in a lipid-binding dependent manner
PICK1 Binding (binding) of
11) Confidence 0.32 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.36 Pain Relevance 0
PICK1 (protein interacting with C kinase 1) is a scaffolding protein that regulates trafficking of multiple membrane proteins [25].
PICK1 Binding (interacting) of
12) Confidence 0.32 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.76 Pain Relevance 0.40
PICK1 2K-E is a lipid binding-deficient mutant with two critical residues of the BAR domain, Lys266 and Lys268, mutated to glutamate [36].
PICK1 Binding (binding) of associated with glutamate
13) Confidence 0.32 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0.05
In addition, and similar to our earlier studies on AMPA receptors [36], the effect of PICK1 on ASIC1a localization and surface also requires the lipid binding of PICK1.
PICK1 Binding (binding) of
14) Confidence 0.32 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.49 Pain Relevance 0.08
Both the PDZ and BAR domains work together and enable PICK1 to couple its PDZ domain-binding partners (e.g.
PICK1 Binding (couple) of
15) Confidence 0.32 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.35 Pain Relevance 0.11
In contrast, PICK1 2K-E had no effect on ASIC1a:PICK1 interaction (Figure 3).
PICK1 Neg (no) Binding (interaction) of
16) Confidence 0.32 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.14 Pain Relevance 0
The interaction of ASIC1a and PICK1 is mediated by the C-terminus of ASIC1a and the PDZ domain of PICK1.
PICK1 Binding (interaction) of
17) Confidence 0.31 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.12 Pain Relevance 0.03
These data indicate that PICK1 enhanced ASIC1a-mediated cell toxicity and this enhancement is dependent on PICK1's lipid binding ability and its interaction with ASIC1a.


PICK1 Binding (interaction) of associated with toxicity
18) Confidence 0.31 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.57 Pain Relevance 0.06
Lipid binding of PICK1 is also required for PICK1-induced clustering of ASIC1a.
PICK1 Binding (binding) of
19) Confidence 0.31 Published 2010 Journal Mol Brain Section Abstract Doc Link PMC3018362 Disease Relevance 0.16 Pain Relevance 0.04
PICK1 interacts with ASICs and this interaction was proposed to regulate the function of ASICs [38-41].
PICK1 Binding (interacts) of associated with asic
20) Confidence 0.31 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.56 Pain Relevance 0.10

General Comments

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