INT1542

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Context Info
Confidence 0.30
First Reported 1978
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 4.25
Pain Relevance 3.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Prss1) extracellular space (Prss1) extracellular region (Prss1)
Prss1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 33 100.00 Very High Very High Very High
opiate 8 98.08 Very High Very High Very High
Pain 1 96.20 Very High Very High Very High
Morphine 2 93.92 High High
methadone 3 92.32 High High
fibrosis 1 89.16 High High
abdominal pain 3 84.56 Quite High
Clonidine 4 75.00 Quite High
agonist 1 75.00 Quite High
antagonist 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Pancreatitis 45 100.00 Very High Very High Very High
Diabetes Mellitus 1 97.80 Very High Very High Very High
Pain 1 96.20 Very High Very High Very High
Ascariasis 1 91.48 High High
Disease 3 90.88 High High
Hyperlipidemia 1 90.88 High High
Obstructive Jaundice 3 90.40 High High
Hypercalcemia 1 90.00 High High
Cystic Fibrosis 1 89.16 High High
Disease Susceptibility 1 88.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An association with gene mutations (PRSS1, SPINK1, CTFR-5T genotype) is suspected.
PRSS1 Binding (association) of
1) Confidence 0.30 Published 2002 Journal Dig. Dis. Sci. Section Abstract Doc Link 12064796 Disease Relevance 1.22 Pain Relevance 0.38
In the last few years, several genes have been identified as being associated with hereditary and idiopathic chronic pancreatitis (CP), i.e.
PRSS1 Binding (associated) of associated with chronic pancreatitis
2) Confidence 0.26 Published 2001 Journal Pancreatology Section Abstract Doc Link 12120220 Disease Relevance 0.57 Pain Relevance 0.48
Notably, p-aminobenzamidine is considered as the prototype of trypsin-like serine protease inhibitors.
trypsin-like serine protease Binding (prototype) of
3) Confidence 0.26 Published 2002 Journal IUBMB Life Section Abstract Doc Link 12587981 Disease Relevance 0 Pain Relevance 0.14
Several genetic mutations, specifically, PRSS1, CFTR, and SPINK1, are associated with chronic pancreatitis.
PRSS1 Binding (associated) of associated with chronic pancreatitis
4) Confidence 0.14 Published 2010 Journal Surgery Section Abstract Doc Link 20846557 Disease Relevance 0.46 Pain Relevance 0.29
No specific microsatellite markers were detected in association with previously reported susceptibility genes for chronic pancreatitis, such as PRSS1, PRSS2, CTRC, SPINK1, CFTR, ALDH2, and CYP2E1.
PRSS1 Binding (association) of associated with chronic pancreatitis
5) Confidence 0.05 Published 2008 Journal Dis. Markers Section Abstract Doc Link 19096130 Disease Relevance 0.57 Pain Relevance 0.44
The strong association of mutations in the PRSS1 gene and in the SPINKI gene with chronic pancreatitis supports the concept of intracellular trypsin activation as an initiating and extremely important step in the development of pancreatitis.
PRSS1 gene Binding (association) of associated with pancreatitis and chronic pancreatitis
6) Confidence 0.01 Published 2005 Journal Clin. Lab. Med. Section Abstract Doc Link 15749232 Disease Relevance 0.72 Pain Relevance 0.42
The strong association of mutations in the PRSS1 gene and in the SPINK1 gene with chronic pancreatitis supports the concept of intracellular trypsin activation as an initiating and extremely important step in the development of pancreatitis.
PRSS1 gene Binding (association) of associated with pancreatitis and chronic pancreatitis
7) Confidence 0.01 Published 2004 Journal Gastroenterol. Clin. North Am. Section Abstract Doc Link 15528018 Disease Relevance 0.72 Pain Relevance 0.42
The electronic structure of all three types of opiates indicate a similar cationic charge distribution around the amine nitrogen and imply that their binding to an anionic receptor site could be similar.
anionic receptor site Binding (binding) of associated with opiate
8) Confidence 0.00 Published 1978 Journal NIDA Res. Monogr. Section Abstract Doc Link 213725 Disease Relevance 0 Pain Relevance 1.17

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