INT154203

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 1.64
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Pick1, Grm7) protein complex (Pick1, Grm7) plasma membrane (Pick1, Grm7)
mitochondrion (Pick1) enzyme binding (Pick1) signal transducer activity (Grm7)
Anatomy Link Frequency
cerebellar granule cell 1
Pick1 (Mus musculus)
Grm7 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 8 99.32 Very High Very High Very High
Kinase C 4 99.20 Very High Very High Very High
Glutamate 8 97.60 Very High Very High Very High
Hippocampus 4 93.36 High High
Pain 4 90.40 High High
Neurotransmitter 4 79.08 Quite High
Glutamate receptor 4 72.92 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 12 93.44 High High
Anxiety Disorder 4 91.40 High High
Pain 4 90.40 High High
Cancer 4 83.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together, these results indicate that PICK1 binding to the C-terminal region of mGluR7a is crucial for agonist-triggered presynaptic signaling in vivo.
PICK1 Binding (binding) of mGluR7 associated with agonist
1) Confidence 0.41 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18716219 Disease Relevance 0.39 Pain Relevance 0.35
Immunoprecipitation showed that the PICK1-mGluR7a interaction is disrupted in mGluR7a(AAA/AAA) mice.
PICK1 Binding (interaction) of mGluR7
2) Confidence 0.40 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18716219 Disease Relevance 0.39 Pain Relevance 0.27
Immunoprecipitation showed that the PICK1-mGluR7a interaction is disrupted in mGluR7a(AAA/AAA) mice.
PICK1 Binding (interaction) of mGluR7
3) Confidence 0.40 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18716219 Disease Relevance 0.39 Pain Relevance 0.27
In cerebellar granule cell cultures, the group III mGluR agonist l-AP-4 decreased the frequency of spontaneous excitatory currents in neurons derived from wild-type but not mGluR7a(AAA/AAA) mice, consistent with the interaction between mGluR7a and PICK1 being required for protein kinase C-mediated inhibition of glutamate release.
PICK1 Binding (interaction) of mGluR7 in cerebellar granule cell associated with glutamate, kinase c and agonist
4) Confidence 0.40 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18716219 Disease Relevance 0.48 Pain Relevance 0.40

General Comments

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