INT154225

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Context Info
Confidence 0.30
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.06
Pain Relevance 3.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkca) endoplasmic reticulum (Prkca) enzyme binding (Prkca)
protein complex (Prkca) cytoplasm (Prkca) cytosol (Prkca)
Prkca (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 42 100.00 Very High Very High Very High
tolerance 34 99.96 Very High Very High Very High
Analgesic 23 99.76 Very High Very High Very High
opioid receptor 84 99.28 Very High Very High Very High
Morphine 88 98.98 Very High Very High Very High
mu opioid receptor 4 96.44 Very High Very High Very High
Kappa opioid receptor 7 92.20 High High
Enkephalin 1 88.16 High High
agonist 3 86.56 High High
Pain 2 63.68 Quite High
Disease Link Frequency Relevance Heat
Pain 4 63.68 Quite High
Urological Neuroanatomy 18 5.00 Very Low Very Low Very Low
Nociception 7 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Intractable Pain 2 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Herpes Simplex Virus Infection 1 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, we found that activity of protein kinase C (PKC) was significantly decreased in mice treated with both U-50488H and morphine.
Negative_regulation (decreased) of PKC Binding (activity) of associated with kinase c and morphine
1) Confidence 0.30 Published 2008 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 18718122 Disease Relevance 0.06 Pain Relevance 2.24
Administration of LNNA or naltrindole before morphine abolished the development of analgesic tolerance, prevented the recruitment of PKC?
Negative_regulation (prevented) of PKC Binding (recruitment) of associated with kinase c, analgesic, tolerance and morphine
2) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 1.47

General Comments

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