INT154226

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Context Info
Confidence 0.28
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.07
Pain Relevance 2.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprk1, Oprm1) plasma membrane (Oprk1, Oprm1) signal transducer activity (Oprk1, Oprm1)
Oprk1 (Mus musculus)
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 11 100.00 Very High Very High Very High
Kappa opioid receptor 7 100.00 Very High Very High Very High
mu opioid receptor 4 100.00 Very High Very High Very High
tolerance 6 96.68 Very High Very High Very High
Enkephalin 1 96.68 Very High Very High Very High
agonist 2 95.08 Very High Very High Very High
Kinase C 3 89.36 High High
Analgesic 4 84.88 Quite High
Pain 1 72.20 Quite High
Disease Link Frequency Relevance Heat
Pain 1 72.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that stimulation of KOR caused by repeated morphine treatment either inhibits MOR desensitization or accelerates recycling of MOR on the cell surface, thereby suppressing morphine tolerance.
Positive_regulation (stimulation) of KOR Negative_regulation (inhibits) of Negative_regulation (desensitization) of MOR associated with tolerance, mu opioid receptor, kappa opioid receptor and morphine
1) Confidence 0.28 Published 2008 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 18718122 Disease Relevance 0.07 Pain Relevance 2.32

General Comments

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