INT154227

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Context Info
Confidence 0.44
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 6
Disease Relevance 3.38
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOD2) plasma membrane (NOD2) enzyme binding (NOD2)
cytoplasm (NOD2)
NOD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Crohn's disease 36 99.96 Very High Very High Very High
Inflammation 46 99.40 Very High Very High Very High
cINOD 4 96.44 Very High Very High Very High
Arthritis 4 73.40 Quite High
tolerance 4 50.32 Quite High
Inflammatory stimuli 4 44.28 Quite Low
cytokine 12 5.00 Very Low Very Low Very Low
abdominal pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 40 99.96 Very High Very High Very High
INFLAMMATION 42 99.40 Very High Very High Very High
Repression 16 96.92 Very High Very High Very High
Syndrome 16 96.40 Very High Very High Very High
Crohn's Disease 24 93.40 High High
Inflammatory Bowel Disease 12 90.32 High High
Granuloma 2 85.16 High High
Cataract 2 79.96 Quite High
Glaucoma 2 78.48 Quite High
Uveitis 4 77.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As in Crohn's disease, CARD15/NOD2 mutation is believed to be responsible for the granulomatous autoinflammatory reactions probably triggered by microorganisms in BS.
Regulation (responsible) of Gene_expression (mutation) of CARD15 associated with crohn's disease, syndrome and disease
1) Confidence 0.44 Published 2009 Journal Autoimmun Rev Section Abstract Doc Link 18718560 Disease Relevance 1.07 Pain Relevance 0.31
As in Crohn's disease, CARD15/NOD2 mutation is believed to be responsible for the granulomatous autoinflammatory reactions probably triggered by microorganisms in BS.
Regulation (responsible) of Gene_expression (mutation) of NOD2 associated with crohn's disease, syndrome and disease
2) Confidence 0.44 Published 2009 Journal Autoimmun Rev Section Abstract Doc Link 18718560 Disease Relevance 1.06 Pain Relevance 0.31
The results provide evidence for a complex regulation of NOD2 expression that includes the alternative usage of two promoters and post-transcriptional regulation of translation by uORFs.


Regulation (regulation) of Gene_expression (expression) of NOD2
3) Confidence 0.27 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2228316 Disease Relevance 0.27 Pain Relevance 0.09
The results suggest complex parallel control mechanisms that independently regulate NOD2 expression in the context of inflammatory signaling.



Regulation (regulate) of Gene_expression (expression) of NOD2 associated with inflammation
4) Confidence 0.27 Published 2007 Journal BMC Genomics Section Abstract Doc Link PMC2228316 Disease Relevance 0.27 Pain Relevance 0.09
However, it is generally accepted that up-regulation of NOD2 expression in intestinal inflammation is a generic response to bacterial invasion and represents a futile attempt to restore the disrupted epithelial barrier in patients with Crohn disease.
Regulation (regulation) of Gene_expression (expression) of NOD2 associated with crohn's disease and inflammation
5) Confidence 0.27 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2228316 Disease Relevance 0.48 Pain Relevance 0.14
Functional characterization of two novel 5' untranslated exons reveals a complex regulation of NOD2 protein expression

Background

Regulation (regulation) of Gene_expression (expression) of NOD2
6) Confidence 0.27 Published 2007 Journal BMC Genomics Section Title Doc Link PMC2228316 Disease Relevance 0.23 Pain Relevance 0.07

General Comments

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