INT154233

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Context Info
Confidence 0.56
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 32
Total Number 38
Disease Relevance 38.89
Pain Relevance 3.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Lox) extracellular region (Lox) proteinaceous extracellular matrix (Lox)
nucleus (Lox)
Anatomy Link Frequency
MDA-MB-231 3
epithelium 2
cleavage 1
Lip 1
mesangial cells 1
Lox (Mus musculus)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 183 99.32 Very High Very High Very High
Inflammation 175 98.52 Very High Very High Very High
medulla 1 95.60 Very High Very High Very High
metalloproteinase 46 95.32 Very High Very High Very High
aspirin 148 93.80 High High
tolerance 1 91.12 High High
imagery 170 90.68 High High
cINOD 338 85.88 High High
Bioavailability 13 79.80 Quite High
cytokine 100 73.24 Quite High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 1512 100.00 Very High Very High Very High
Apoptosis 792 99.76 Very High Very High Very High
Cancer 2720 99.64 Very High Very High Very High
Adhesions 160 99.56 Very High Very High Very High
Metastasis 1010 99.24 Very High Very High Very High
Diabetes Mellitus 1 98.92 Very High Very High Very High
INFLAMMATION 225 98.52 Very High Very High Very High
Injury 17 97.72 Very High Very High Very High
Immunotherapy Of Cancer 36 97.48 Very High Very High Very High
Disease 76 96.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results suggest that LOX plays an important role in extravasation and/or tissue colonization by tumor cells, lending support to the idea that LOX inhibition might be useful in metastasis prevention.



Negative_regulation (inhibition) of LOX associated with cancer and metastasis
1) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680032 Disease Relevance 0.75 Pain Relevance 0
1) with BAPN was likely a result of LOX inhibition during the initial steps of tumor cell interaction with the blood vessel epithelium; while the effect of BAPN in the ‘day 0’ group may have been due LOX inhibition during the later stages of extravasation and initial tissue colonization.
Negative_regulation (inhibition) of LOX in epithelium associated with cancer
2) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680032 Disease Relevance 0.64 Pain Relevance 0
1) with BAPN was likely a result of LOX inhibition during the initial steps of tumor cell interaction with the blood vessel epithelium; while the effect of BAPN in the ‘day 0’ group may have been due LOX inhibition during the later stages of extravasation and initial tissue colonization.
Negative_regulation (inhibition) of LOX in epithelium associated with cancer
3) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680032 Disease Relevance 0.69 Pain Relevance 0
We therefore evaluated the ability of the irreversible LOX inhibitor, ?
Negative_regulation (inhibitor) of LOX
4) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680032 Disease Relevance 1.32 Pain Relevance 0.03
To evaluate the effect of LOX inhibition on the development of metastases, we introduced MDA-MB-231-Luc2 cells into the arterial circulation of NIH-III mice via intra-cardiac injection and then monitored the development of tumors at regular intervals using bioluminescence imaging.
Negative_regulation (inhibition) of LOX in MDA-MB-231 associated with cancer, imagery and metastasis
5) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680032 Disease Relevance 0.44 Pain Relevance 0.05
Both up- and down-regulation of LOX has been observed in different cancer cell lines and primary tumors (reviewed in [21]), however, in breast cancer, elevated LOX expression has been positively-correlated with invasiveness, as well as with reduced metastasis-free and overall survival [16], [22], [23], [24], [25].
Negative_regulation (regulation) of LOX associated with cancer, breast cancer and metastasis
6) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680032 Disease Relevance 1.05 Pain Relevance 0.05
We used the MDA-MB-231-Luc2 xenograft system to demonstrate that the LOX inhibitor, ?
Negative_regulation (inhibitor) of LOX in MDA-MB-231
7) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680032 Disease Relevance 0.89 Pain Relevance 0.03
However, the question remained as to whether LOX inhibition was acting (a) to prevent the migration of cells away from the primary tumor, (b) by limiting tumor cell intravasation, (c) by blocking extravasation, or (d) by decreasing the ability of the tumor cells to colonize favorable niches within distant sites.
Spec (whether) Negative_regulation (inhibition) of LOX associated with cancer
8) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680032 Disease Relevance 1.29 Pain Relevance 0.03
Our findings suggest that LOX activity is required during extravasation and/or initial tissue colonization by circulating MDA-MB-231 cells, lending support to the idea that LOX inhibition might be useful in metastasis prevention.



Negative_regulation (inhibition) of LOX in MDA-MB-231 associated with metastasis
9) Confidence 0.41 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2680032 Disease Relevance 0.98 Pain Relevance 0.04
In summary, the LOX inhibitor, BAPN, was able to significantly decrease the frequency of metastases in animals were challenged by the introduction of large number of breast cancer cells directly into the arterial circulation.
Negative_regulation (inhibitor) of LOX associated with breast cancer and metastasis
10) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680032 Disease Relevance 1.02 Pain Relevance 0
Mice were exposed to a 4-kHz pure tone of 128 dB SPL (sound pressure level) for 4 hours and received one of the following drugs for two weeks after acoustic overexposure: indomethacin (COX-1 inhibitor), meloxicam, SC58125, and CAY10404 (COX-2 inhibitors), and nordihydroguaiaretic acid (LOX inhibitor).
Negative_regulation (inhibitor) of LOX associated with cox-2 inhibitor
11) Confidence 0.35 Published 2008 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 18719338 Disease Relevance 0.59 Pain Relevance 0.45
Indeed, TM treatment of OSCC-3 cells significantly inhibited LOX activity (Fig. 4C).
Negative_regulation (inhibited) of LOX
12) Confidence 0.31 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2922193 Disease Relevance 0.92 Pain Relevance 0
TM treatment significantly decreased tumor cell motility and invasiveness by inhibiting lysyl oxidase (LOX) activity, FAK activation and MMP2 levels.
Negative_regulation (inhibiting) of LOX associated with cancer
13) Confidence 0.31 Published 2010 Journal Mol Cancer Section Abstract Doc Link PMC2922193 Disease Relevance 1.55 Pain Relevance 0.03
Our results suggest that TM treatment significantly inhibits HNSCC metastasis by decreasing tumor cell motility by inhibiting lysyl oxidase and focal adhesion kinase.
Negative_regulation (inhibiting) of lysyl oxidase associated with cancer, adhesions and metastasis
14) Confidence 0.31 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2922193 Disease Relevance 1.32 Pain Relevance 0.08
TM treatment significantly decreased tumor cell motility and invasiveness by inhibiting lysyl oxidase (LOX) activity, FAK activation and MMP2 levels.
Negative_regulation (inhibiting) of lysyl oxidase associated with cancer
15) Confidence 0.31 Published 2010 Journal Mol Cancer Section Abstract Doc Link PMC2922193 Disease Relevance 1.55 Pain Relevance 0.03
Therefore, TM may be inhibiting tumor cell migration by inhibiting FAK activation via lysyl oxidase.
Negative_regulation (inhibiting) of lysyl oxidase associated with cancer
16) Confidence 0.30 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2922193 Disease Relevance 1.03 Pain Relevance 0.04
We next examined if TM mediated its inhibitory effect on tumor cell motility by inhibiting LOX.
Negative_regulation (inhibiting) of LOX associated with cancer
17) Confidence 0.27 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2922193 Disease Relevance 0.99 Pain Relevance 0
To confirm that apoptosis occurs in pancreatic cancer cells following LOX inhibitor treatment, we conducted further studies that showed that LOX inhibitors reduce expression of Bcl-2 and Mcl-1 and induce activation of caspase-3 and -9 as well as cleavage of the caspase-3 target, PARP [53,54].


Negative_regulation (inhibitors) of LOX in cleavage associated with pancreatic cancer and apoptosis
18) Confidence 0.25 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 1.11 Pain Relevance 0.03
The anti-pancreatic cancer activity of this extract is probably mediated through inhibition of LOX activity, since it inhibits LTB4 secretion.
Negative_regulation (inhibition) of LOX associated with pancreatic cancer
19) Confidence 0.25 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 1.04 Pain Relevance 0
There are, of course, certain problems which need to be solved before the use of COX and LOX enzyme inhibitors can be translated into the clinic for pancreatic cancer treatment and prevention.
Negative_regulation (inhibitors) of LOX enzyme associated with pancreatic cancer
20) Confidence 0.25 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 0.98 Pain Relevance 0.23

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