INT154237

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Context Info
Confidence 0.41
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.75
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (CYP2D6, Ugt2b7) mitochondrion (CYP2D6) small molecule metabolic process (CYP2D6)
oxidoreductase activity (CYP2D6) molecular_function (Ugt2b7) cellular_component (Ugt2b7)
Anatomy Link Frequency
CNS 1
CYP2D6 (Homo sapiens)
Ugt2b7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 5 97.64 Very High Very High Very High
depression 3 97.44 Very High Very High Very High
Codeine 9 94.52 High High
Opioid 2 75.00 Quite High
pain labor 1 63.08 Quite High
Pain 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Depression 4 98.44 Very High Very High Very High
Toxicity 3 95.56 Very High Very High Very High
Poisoning 1 65.64 Quite High
Labor Pain 1 63.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Breastfed infants of mothers who are CYP2D6 UMs combined with the UGT2B7*2/*2 are at increased risk of potentially life-threatening CNS depression.
CYP2D6 Binding (combined) of UGT2B7 in CNS associated with depression and central nervous system
1) Confidence 0.41 Published 2009 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 18719619 Disease Relevance 0.75 Pain Relevance 1.00

General Comments

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