INT154243

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.86
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Alms1) cilium (Alms1) molecular_function (Alms1)
lipid metabolic process (Alms1) cytoplasm (Alms1)
Anatomy Link Frequency
CNS 2
Alms1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 51 98.28 Very High Very High Very High
Neuropathic pain 1 84.56 Quite High
Multiple sclerosis 2 80.92 Quite High
depression 1 79.72 Quite High
Inflammation 9 42.64 Quite Low
tolerance 1 30.72 Quite Low
Morphine 20 5.00 Very Low Very Low Very Low
Oxycodone 11 5.00 Very Low Very Low Very Low
chemokine 9 5.00 Very Low Very Low Very Low
Opioid 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 15 97.32 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 110 90.72 High High
Targeted Disruption 4 86.68 High High
Infection 34 85.76 High High
Schizophrenia 1 85.32 High High
Neuropathic Pain 1 84.56 Quite High
Neurodegenerative Disease 1 82.24 Quite High
Demyelinating Disease 3 80.92 Quite High
Epilepsy 1 80.12 Quite High
Depression 1 79.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Novel technologies, capable of enhancing BBB permeation, are also discussed relative to improving CNS therapies for these disease states.
Positive_regulation (enhancing) of BBB Binding (permeation) of in CNS associated with central nervous system and disease
1) Confidence 0.42 Published 2008 Journal Drug Dev Ind Pharm Section Abstract Doc Link 18720140 Disease Relevance 0.98 Pain Relevance 0.32
The risk of a drug interaction at the BBB is also increased if one transporter dominates the transport.
Positive_regulation (increased) of BBB Binding (interaction) of
2) Confidence 0.20 Published 2007 Journal Pharm Res Section Body Doc Link PMC2469271 Disease Relevance 0 Pain Relevance 0
Oral administration of PCBs disrupts BBB integrity
Positive_regulation (disrupts) of BBB Binding (integrity) of
3) Confidence 0.08 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854723 Disease Relevance 0.05 Pain Relevance 0
Partial impairment of the BBB was induced by systemic LPS.
Positive_regulation (induced) of BBB Neg (impairment) Spec (Partial) Binding (impairment) of
4) Confidence 0.06 Published 2010 Journal Retrovirology Section Body Doc Link PMC2864195 Disease Relevance 0.83 Pain Relevance 0

General Comments

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