INT154282

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Context Info
Confidence 0.55
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.41
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (WT1) nucleolus (WT1) RNA binding (WT1)
nucleus (WT1) intracellular (WT1) cytoplasm (WT1)
Anatomy Link Frequency
neurons 2
bone marrow 2
WT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 2 99.20 Very High Very High Very High
Pain 6 95.08 Very High Very High Very High
chemokine 16 5.00 Very Low Very Low Very Low
cytokine 14 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
Freund adjuvant 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 103 100.00 Very High Very High Very High
Cancer 96 99.82 Very High Very High Very High
Malignant Neoplastic Disease 6 99.72 Very High Very High Very High
Endometriosis (extended) 2 99.20 Very High Very High Very High
Myeloid Leukemia 82 98.70 Very High Very High Very High
Ulcers 24 95.44 Very High Very High Very High
Pain 5 95.08 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 116 74.40 Quite High
Cold Sores 108 63.52 Quite High
Infection 33 61.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All patients were HLA-A2402 positive and their malignant cells showed high WT1 expression.
Positive_regulation (high) of Gene_expression (expression) of WT1 associated with malignant neoplastic disease
1) Confidence 0.55 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896720 Disease Relevance 1.00 Pain Relevance 0
Wilms' tumor gene 1 (WT1) overexpression in neurons in deep endometriosis: a pilot study.
Positive_regulation (overexpression) of Gene_expression (overexpression) of WT1 in neurons associated with endometriosis and cancer
2) Confidence 0.49 Published 2009 Journal Fertil. Steril. Section Title Doc Link 18722603 Disease Relevance 0.39 Pain Relevance 0.19
It is noteworthy that the efficacy of circumcision for prevention of clinically observed GUD at time of a study visit (PRR?
Positive_regulation (observed) of Gene_expression (observed) of GUD associated with disease
3) Confidence 0.41 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2771764 Disease Relevance 1.07 Pain Relevance 0
Only 10 of these patients could be evaluated with regard to clinical responses: (i) 2 patients showed decreased residual AML; (ii) stable disease was seen for 2 patients; (iii) bone marrow expression of WT1 was used as a surrogate marker of residual disease for those patients without detectable AML blasts, and for 5 of these patients decreased expression was detected following vaccination; (iv) 1 patient showed progressive disease.
Positive_regulation (used) of Gene_expression (expression) of WT1 in bone marrow associated with myeloid leukemia and disease
4) Confidence 0.39 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896720 Disease Relevance 0.95 Pain Relevance 0

General Comments

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