INT154309

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Context Info
Confidence 0.66
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 6.79
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
Nasal 2
Bar 1
striatum 1
globus pallidus 1
platelet 1
gp (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 6 99.96 Very High Very High Very High
antagonist 7 99.74 Very High Very High Very High
substance P 6 98.66 Very High Very High Very High
Neuropeptide 1 97.76 Very High Very High Very High
Substantia nigra 7 97.40 Very High Very High Very High
projection neuron 2 95.14 Very High Very High Very High
Paracetamol 1 93.36 High High
Dopamine 21 93.12 High High
Pain 58 93.08 High High
headache 36 90.64 High High
Disease Link Frequency Relevance Heat
Ebola Virus Infection 275 100.00 Very High Very High Very High
Parainfluenza Virus Infection 5 99.66 Very High Very High Very High
Sinusitis 5 99.50 Very High Very High Very High
Catalepsy 54 96.40 Very High Very High Very High
Immunization 130 94.56 High High
Pain 63 93.08 High High
Dyspnea 12 91.80 High High
Headache 36 90.64 High High
Bacterial Respiratory Disease 2 89.72 High High
Fatigue 32 88.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Secondly, were the symptoms presented to the GP associated with a high level of functional impairment and distress?
Gene_expression (presented) of GP
1) Confidence 0.66 Published 2007 Journal BMC Health Serv Res Section Abstract Doc Link PMC2140058 Disease Relevance 0 Pain Relevance 0
The majority of symptoms reported by survivors of the fireworks disaster was not presented to the GP.
Neg (not) Gene_expression (presented) of GP
2) Confidence 0.58 Published 2007 Journal BMC Health Serv Res Section Body Doc Link PMC2140058 Disease Relevance 0.88 Pain Relevance 0.45
There may be some false negatives, and the percentage of survivors presenting self-reported symptoms may be an underestimation of the actual number of symptoms that are presented to the GP.
Gene_expression (presented) of GP
3) Confidence 0.58 Published 2007 Journal BMC Health Serv Res Section Body Doc Link PMC2140058 Disease Relevance 0 Pain Relevance 0
Firstly, were self-reported symptoms among survivors presented to the GP?
Gene_expression (presented) of GP
4) Confidence 0.58 Published 2007 Journal BMC Health Serv Res Section Abstract Doc Link PMC2140058 Disease Relevance 0 Pain Relevance 0
Each year, around 20 in every 1,000 people in the UK consult their GP about a suspected sinus infection,1 which means that each GP sees an average of about 50 such cases annually.2 Although most people recover from acute sinusitis with or without treatment within 10 days of seeing a GP,2 it is estimated that around 92% of those who consult their GP with a sinus infection are prescribed an antibacterial.1 Here we review the management of patients with acute sinusitis, and the place of antibacterial and other treatments.
Gene_expression (sees) of GP in sinus associated with sinusitis and bacterial respiratory disease
5) Confidence 0.54 Published 2009 Journal Drug Ther Bull Section Abstract Doc Link 19261837 Disease Relevance 0.63 Pain Relevance 0
The contribution of gluconeogenesis to hepatic glucose production (GP) was quantified after (2)H(2)O ingestion by Bayesian analysis of the position 2 and 5 (2)H-NMR signals (H2 and H5) of monoacetone glucose (MAG) derived from urinary acetaminophen glucuronide.
Gene_expression (production) of GP associated with paracetamol
6) Confidence 0.40 Published 2008 Journal Magn Reson Med Section Abstract Doc Link 18727053 Disease Relevance 0.07 Pain Relevance 0.09
The results of this study indicate that there are no major differences in diagnosis and prognosis of knee complaints between athletes and non-athletes presented to the GP.
Gene_expression (presented) of GP in knee
7) Confidence 0.33 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2278141 Disease Relevance 0.16 Pain Relevance 0.16
Medium-spiny projection neurons in the striatum can be largely subdivided into two groups: some that project to directly to the substantia nigra pars reticulata (SNr) (the direct pathway) express substance P; others that project to the same nucleus via the globus pallidus (GP) (the indirect pathway) express enkephalin [29].
Gene_expression (express) of GP in globus pallidus associated with substantia nigra, enkephalin, projection neuron and substance p
8) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2613534 Disease Relevance 0 Pain Relevance 0.54
Blood platelet counts (Fig. 1 D), mean platelet volume, and expression levels of major platelet surface receptors, including glycoprotein (GP) Ib-V-IX, GPVI, CD9, and ?
Gene_expression (expression) of GP in platelet
9) Confidence 0.13 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442636 Disease Relevance 0.30 Pain Relevance 0
The first protocol for an Ebola vaccine employed a prime-boost regimen consisting of naked DNA expressing either Ebola glycoprotein (GP) or nucleoprotein (NP) and recombinant Ad5 expressing Ebola GP to successfully protect non-human primates against a lethal challenge of Ebola [33].
Gene_expression (expressing) of GP associated with ebola virus infection
10) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2569416 Disease Relevance 0.73 Pain Relevance 0
Nasal administration of recombinant human parainfluenza virus type 3 (HPIV3) vectors expressing Ebola GP and/or NP to Guinea pigs and rhesus monkeys conferred complete protection against a lethal challenge with Ebola.
Gene_expression (expressing) of GP in Nasal associated with ebola virus infection and parainfluenza virus infection
11) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2569416 Disease Relevance 1.00 Pain Relevance 0
We have previously found that a single dose of a recombinant adenovirus expressing Ebola Zaire GP given by either the oral or the nasal route is capable of affording protection against lethal challenge in naïve mice and that mucosal immunization can stimulate a broad, prolonged T cell-mediated immune response in both the systemic and mucosal compartments [37].
Gene_expression (expressing) of GP in nasal associated with ebola virus infection and immunization
12) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2569416 Disease Relevance 1.05 Pain Relevance 0
The first protocol for an Ebola vaccine employed a prime-boost regimen consisting of naked DNA expressing either Ebola glycoprotein (GP) or nucleoprotein (NP) and recombinant Ad5 expressing Ebola GP to successfully protect non-human primates against a lethal challenge of Ebola [33].
Gene_expression (expressing) of GP associated with ebola virus infection
13) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2569416 Disease Relevance 0.75 Pain Relevance 0
The first protocol for an Ebola vaccine employed a prime-boost regimen consisting of naked DNA expressing either Ebola glycoprotein (GP) or nucleoprotein (NP) and recombinant Ad5 expressing Ebola GP to successfully protect non-human primates against a lethal challenge of Ebola [33].
Gene_expression (expressing) of GP associated with ebola virus infection
14) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2569416 Disease Relevance 0.75 Pain Relevance 0
The Bar test measurements showed that after selective ibotenic acid lesions of the GP, ?
Gene_expression (lesions) of GP in Bar
15) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704377 Disease Relevance 0.26 Pain Relevance 0
In agreement with this hypothesis, previous studies have shown that systemic administration of D2 antagonists induced Fos expression, the protein product of the immediate early gene c-fos, in the GP by its direct action within GP and not within the striatum [3], [4], [46].
Gene_expression (expression) of GP in striatum associated with antagonist
16) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704377 Disease Relevance 0.08 Pain Relevance 0.28
Responses of GP neurons to ?
Gene_expression (neurons) of GP in neurons
17) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704377 Disease Relevance 0 Pain Relevance 0
The following excerpt is one GP's response to being asked about how he would manage a patient who he considered to be an 'overuser':
Gene_expression (response) of GP
18) Confidence 0.03 Published 2010 Journal Harm Reduct J Section Body Doc Link PMC2958156 Disease Relevance 0.14 Pain Relevance 0.07

General Comments

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