INT154312

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Context Info
Confidence 0.54
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 3.17
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (STON1)
Anatomy Link Frequency
neurons 1
STN 1
thalamus 1
STON1 (Homo sapiens)
Pain Link Frequency Relevance Heat
deep brain stimulation 229 100.00 Very High Very High Very High
Thalamus 124 99.64 Very High Very High Very High
palliative 8 86.72 High High
Calcium channel 5 82.24 Quite High
Serotonin 1 80.84 Quite High
gABA 1 80.36 Quite High
Glutamate 1 79.12 Quite High
Opioid 1 78.68 Quite High
Cannabinoid 1 78.36 Quite High
Dopamine 33 77.84 Quite High
Disease Link Frequency Relevance Heat
Cancer 202 100.00 Very High Very High Very High
Cognitive Disorder 12 97.48 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 3 96.52 Very High Very High Very High
Hypokinesia 20 96.44 Very High Very High Very High
Disease 287 93.24 High High
Tremor 40 91.52 High High
Hematologic Neoplasms 2 82.84 Quite High
Multiple Myeloma 4 81.00 Quite High
Parkinson's Disease 104 80.24 Quite High
Disease Progression 4 64.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Part II of the two volumes (volume 199) on the subthalamic nucleus (STN) starts with a systemic model of the basal ganglia to evaluate the position of the STN in the direct, indirect and hyperdirect pathways.
Gene_expression (position) of STN in STN
1) Confidence 0.54 Published 2008 Journal Adv Anat Embryol Cell Biol Section Abstract Doc Link 18727483 Disease Relevance 0.07 Pain Relevance 0.38
To model the STN neurons, and bring out their rebound excitability, Terman et al. (2002) model the STN membrane current as a combination of
Gene_expression (neurons) of STN in neurons
2) Confidence 0.17 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944387 Disease Relevance 0 Pain Relevance 0
Although the STN is now the dominant DBS target, it is unclear whether the GPi, with a less burdensome set of cognitive side effects, might be better for some patients (Anderson et al. 2005).
Gene_expression (target) of STN associated with cognitive disorder and deep brain stimulation
3) Confidence 0.17 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944387 Disease Relevance 0.83 Pain Relevance 0.38
The STN excites the GPe.
Gene_expression (excites) of STN
4) Confidence 0.17 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944387 Disease Relevance 0.40 Pain Relevance 0.07
We can now relatively safely place electrodes in the STN, GPi or thalamus.9
Gene_expression (electrodes) of STN in thalamus associated with thalamus
5) Confidence 0.17 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944387 Disease Relevance 0.55 Pain Relevance 0.17
Theratope is an investigational therapeutic cancer vaccine consisting of a synthetic form of the tumor associated antigen Sialyl Tn (STn) conjugated to the carrier protein keyhole limpet hemocyanin (KLH).
Gene_expression (synthetic) of STn associated with cancer
6) Confidence 0.06 Published 2004 Journal J Transl Med Section Body Doc Link PMC441417 Disease Relevance 1.31 Pain Relevance 0

General Comments

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