INT154333

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Context Info
Confidence 0.69
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 3.90
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (S100A12) extracellular region (S100A12) nucleus (S100A12)
cytoplasm (S100A12)
Anatomy Link Frequency
bowel 2
S100A12 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 22 100.00 Very High Very High Very High
spastic colon 3 89.76 High High
Crohn's disease 3 86.88 High High
chemokine 3 80.24 Quite High
headache 1 36.24 Quite Low
Central nervous system 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Peripheral nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 13 100.00 Very High Very High Very High
Inflammatory Bowel Disease 15 99.72 Very High Very High Very High
Oxyphilic Adenoma 5 98.94 Very High Very High Very High
Cancer 113 98.60 Very High Very High Very High
Disease 15 98.08 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

3 89.96 High High
Functional Bowel Disorder 3 89.76 High High
Adhesions 3 82.08 Quite High
Rhinitis 3 80.12 Quite High
Pituitary Cancer 1 76.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found an increased spontaneous release of S100A12 from tissue in inflammatory bowel disease (IBD).
Positive_regulation (increased) of Localization (release) of S100A12 in bowel associated with inflammatory bowel disease and inflammation
1) Confidence 0.69 Published 2008 Journal J. Pathol. Section Abstract Doc Link 18729068 Disease Relevance 0.93 Pain Relevance 0.37
The release of S100A12 into the supernatants was 28-fold enhanced in inflamed tissue when compared to non-inflamed tissue (mean 46.9 vs. 1.7 ng/ml, p < 0.0001).
Positive_regulation (enhanced) of Localization (release) of S100A12
2) Confidence 0.69 Published 2008 Journal J. Pathol. Section Abstract Doc Link 18729068 Disease Relevance 0.94 Pain Relevance 0.37
In active CD, release of S100A12 and MRP8/14 was strongly dependent on localization, with little release from sites of active ileal inflammation compared to colonic inflammation.
Positive_regulation (dependent) of Localization (release) of S100A12 associated with inflammation
3) Confidence 0.50 Published 2008 Journal J. Pathol. Section Abstract Doc Link 18729068 Disease Relevance 0.94 Pain Relevance 0.40
The code 8291/0 has been proposed for the fourth edition of ICD-O.Fig. 5Spindle cell oncocytoma. a Note spindle and somewhat epithelioid cells with abundance of variably granular cytoplasm, different degrees of nuclear atypia and focal inflammatory reaction. b Generalized staining for S-100 protein is a regular feature of this rare tumour


Positive_regulation (for) of Localization (abundance) of S-100 protein associated with inflammation, cancer and oxyphilic adenoma
4) Confidence 0.15 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC1929165 Disease Relevance 0.84 Pain Relevance 0.05

General Comments

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