INT154333

Context Info Confidence 0.69 First Reported 2007 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 4 Total Number 4 Disease Relevance 3.90 Pain Relevance 1.19

cytosol (S100A12) extracellular region (S100A12) nucleus (S100A12) cytoplasm (S100A12)

Anatomy Link Frequency bowel 2 S100A12 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 22 100.00 spastic colon 3 89.76 Crohn's disease 3 86.88 chemokine 3 80.24 headache 1 36.24 Central nervous system 3 5.00 imagery 3 5.00 Spinal cord 2 5.00 Peripheral nervous system 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 13 100.00 Inflammatory Bowel Disease 15 99.72 Oxyphilic Adenoma 5 98.94 Cancer 113 98.60 Disease 15 98.08 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super 3 89.96 Functional Bowel Disorder 3 89.76 Adhesions 3 82.08 Rhinitis 3 80.12 Pituitary Cancer 1 76.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We found an increased spontaneous release of S100A12 from tissue in inflammatory bowel disease (IBD).

Positive_regulation (increased) of Localization (release) of S100A12 in bowel associated with inflammatory bowel disease and inflammation

1) Confidence 0.69 Published 2008 Journal J. Pathol. Section Abstract Doc Link 18729068 Disease Relevance 0.93 Pain Relevance 0.37

The release of S100A12 into the supernatants was 28-fold enhanced in inflamed tissue when compared to non-inflamed tissue (mean 46.9 vs. 1.7 ng/ml, p < 0.0001).

Positive_regulation (enhanced) of Localization (release) of S100A12

2) Confidence 0.69 Published 2008 Journal J. Pathol. Section Abstract Doc Link 18729068 Disease Relevance 0.94 Pain Relevance 0.37

In active CD, release of S100A12 and MRP8/14 was strongly dependent on localization, with little release from sites of active ileal inflammation compared to colonic inflammation.

Positive_regulation (dependent) of Localization (release) of S100A12 associated with inflammation

3) Confidence 0.50 Published 2008 Journal J. Pathol. Section Abstract Doc Link 18729068 Disease Relevance 0.94 Pain Relevance 0.40

The code 8291/0 has been proposed for the fourth edition of ICD-O.Fig. 5Spindle cell oncocytoma. a Note spindle and somewhat epithelioid cells with abundance of variably granular cytoplasm, different degrees of nuclear atypia and focal inflammatory reaction. b Generalized staining for S-100 protein is a regular feature of this rare tumour

Positive_regulation (for) of Localization (abundance) of S-100 protein associated with inflammation, cancer and oxyphilic adenoma

4) Confidence 0.15 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC1929165 Disease Relevance 0.84 Pain Relevance 0.05

General Comments

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