INT154334
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
The release of S100A12 into the supernatants was 28-fold enhanced in inflamed tissue when compared to non-inflamed tissue (mean 46.9 vs. 1.7 ng/ml, p < 0.0001). | |||||||||||||||
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In the present study we analyse the release of S100A12 and MRP8/14 from intestinal tissue. | |||||||||||||||
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We found an increased spontaneous release of S100A12 from tissue in inflammatory bowel disease (IBD). | |||||||||||||||
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In active CD, release of S100A12 and MRP8/14 was strongly dependent on localization, with little release from sites of active ileal inflammation compared to colonic inflammation. | |||||||||||||||
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The data presented by Foell et al, on the other hand, were indicative of a predominant mucosal release of S100A12, from the inflamed colon of CD patients. | |||||||||||||||
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The direct release of phagocyte-derived S100 proteins from inflamed tissues may reflect secretion from infiltrating neutrophils (S100A12) and also monocytes or epithelial cells (MRP8/14). | |||||||||||||||
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S100A12, a calcium-binding proinflammatory protein secreted by granulocytes, has been associated with different diseases of inflammatory origin, including inflammatory bowel disease (IBD). | |||||||||||||||
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The predominant role of the innate immune system in systemic onset disease is also underscored by the high expression and serum concentrations of the calcium-binding proteins S100A8, S100A9, and S100A12, which are specifically secreted during activation of neutrophilic granulocytes and monocytes47). | |||||||||||||||
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The code 8291/0 has been proposed for the fourth edition of ICD-O.Fig. 5Spindle cell oncocytoma. a Note spindle and somewhat epithelioid cells with abundance of variably granular cytoplasm, different degrees of nuclear atypia and focal inflammatory reaction. b Generalized staining for S-100 protein is a regular feature of this rare tumour
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