INT154334

Context Info Confidence 0.80 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 9 Total Number 9 Disease Relevance 9.32 Pain Relevance 2.89

cytosol (S100A12) extracellular region (S100A12) nucleus (S100A12) cytoplasm (S100A12)

Anatomy Link Frequency bowel 2 colon 1 immune system 1 neutrophils 1 S100A12 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 76 100.00 spastic colon 53 99.48 Crohn's disease 75 98.84 chemokine 6 92.52 cytokine 18 90.20 Piles 2 84.52 Arthritis 21 78.48 rheumatoid arthritis 64 63.64 Inflammatory marker 8 59.60 antagonist 1 49.84

Disease Link Frequency Relevance Heat INFLAMMATION 62 100.00 Inflammatory Bowel Disease 191 99.72 Functional Bowel Disorder 11 99.48 Oxyphilic Adenoma 5 98.94 Disease 223 98.84 Cancer 114 98.60 Colitis 4 95.88 Ileitis 2 92.52 Adhesions 5 91.52 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super 47 89.08

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Mutation

Event

Anatomy

Negation

Speculation

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Disease term

The release of S100A12 into the supernatants was 28-fold enhanced in inflamed tissue when compared to non-inflamed tissue (mean 46.9 vs. 1.7 ng/ml, p < 0.0001).

Localization (release) of S100A12

1) Confidence 0.80 Published 2008 Journal J. Pathol. Section Abstract Doc Link 18729068 Disease Relevance 0.93 Pain Relevance 0.37

In the present study we analyse the release of S100A12 and MRP8/14 from intestinal tissue.

Localization (release) of S100A12

2) Confidence 0.80 Published 2008 Journal J. Pathol. Section Abstract Doc Link 18729068 Disease Relevance 0.63 Pain Relevance 0.25

We found an increased spontaneous release of S100A12 from tissue in inflammatory bowel disease (IBD).

Localization (release) of S100A12 in bowel associated with inflammatory bowel disease and inflammation

3) Confidence 0.80 Published 2008 Journal J. Pathol. Section Abstract Doc Link 18729068 Disease Relevance 0.92 Pain Relevance 0.36

In active CD, release of S100A12 and MRP8/14 was strongly dependent on localization, with little release from sites of active ileal inflammation compared to colonic inflammation.

Localization (release) of S100A12 associated with inflammation

4) Confidence 0.80 Published 2008 Journal J. Pathol. Section Abstract Doc Link 18729068 Disease Relevance 0.93 Pain Relevance 0.38

The data presented by Foell et al, on the other hand, were indicative of a predominant mucosal release of S100A12, from the inflamed colon of CD patients.

Localization (release) of S100A12 in colon associated with crohn's disease

5) Confidence 0.80 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2964606 Disease Relevance 1.51 Pain Relevance 0.31

The direct release of phagocyte-derived S100 proteins from inflamed tissues may reflect secretion from infiltrating neutrophils (S100A12) and also monocytes or epithelial cells (MRP8/14).

Localization (secretion) of S100A12 in neutrophils

6) Confidence 0.65 Published 2008 Journal J. Pathol. Section Abstract Doc Link 18729068 Disease Relevance 0.79 Pain Relevance 0.37

S100A12, a calcium-binding proinflammatory protein secreted by granulocytes, has been associated with different diseases of inflammatory origin, including inflammatory bowel disease (IBD).

Localization (secreted) of S100A12 in bowel associated with inflammatory bowel disease, inflammation and disease

7) Confidence 0.61 Published 2010 Journal BMC Gastroenterol Section Abstract Doc Link PMC2964606 Disease Relevance 1.08 Pain Relevance 0.57

The predominant role of the innate immune system in systemic onset disease is also underscored by the high expression and serum concentrations of the calcium-binding proteins S100A8, S100A9, and S100A12, which are specifically secreted during activation of neutrophilic granulocytes and monocytes47).

Localization (secreted) of S100A12 in immune system associated with disease

8) Confidence 0.24 Published 2010 Journal Korean Journal of Pediatrics Section Body Doc Link PMC3012271 Disease Relevance 1.07 Pain Relevance 0.24

The code 8291/0 has been proposed for the fourth edition of ICD-O.Fig. 5Spindle cell oncocytoma. a Note spindle and somewhat epithelioid cells with abundance of variably granular cytoplasm, different degrees of nuclear atypia and focal inflammatory reaction. b Generalized staining for S-100 protein is a regular feature of this rare tumour

Localization (abundance) of S-100 protein associated with inflammation, cancer and oxyphilic adenoma

9) Confidence 0.22 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC1929165 Disease Relevance 0.84 Pain Relevance 0.05

General Comments

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