INT154372

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Context Info
Confidence 0.54
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.27
Pain Relevance 1.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
immune system 1
dorsal root ganglion 1
microglia 1
Cd163 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
c fibre 148 99.18 Very High Very High Very High
dorsal root ganglion 7 99.08 Very High Very High Very High
metalloproteinase 8 94.20 High High
chemokine 4 93.16 High High
Neuropathic pain 8 86.52 High High
Dorsal horn 70 83.92 Quite High
Inflammatory response 2 79.40 Quite High
induced neuropathy 1 75.00 Quite High
Sciatic nerve 62 72.72 Quite High
peripheral neuropathy 1 65.44 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 8 98.60 Very High Very High Very High
Injury 18 90.24 High High
Neuropathic Pain 22 86.52 High High
INFLAMMATION 15 79.04 Quite High
Hypersensitivity 19 73.84 Quite High
Peripheral Neuropathy 1 65.44 Quite High
Pain 26 42.56 Quite Low
Hyperalgesia 18 33.52 Quite Low
Graft Vs Host Disease 7 9.32 Low Low
Nervous System Injury 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By reverse transcription-polymerase chain reaction, the expression levels of MMP-3 and CD163 were markedly up-regulated in paclitaxel-treated dorsal root ganglion.
Positive_regulation (up-regulated) of CD163 in dorsal root ganglion associated with ganglion cysts and dorsal root ganglion
1) Confidence 0.54 Published 2008 Journal Cancer Sci. Section Abstract Doc Link 18754875 Disease Relevance 0.95 Pain Relevance 0.68
The second phase is consistent with the maintenance of microglial activation and their migration to the affected tissue with upregulation of the markers CD163 and CSFR1 24 h post C-fibre stimulation.
Positive_regulation (upregulation) of CD163 associated with c fibre
2) Confidence 0.47 Published 2009 Journal Pain Section Body Doc Link PMC2702711 Disease Relevance 0.07 Pain Relevance 0.54
The upregulation we observed with CSF-1 is again indicative of C-fibre evoked microglial activation whilst the increases in CD163 and absence of change in CD68 lead us to conclude that it is resident microglia that are activated following our stimulation paradigm.
Positive_regulation (increases) of CD163 in microglia associated with c fibre
3) Confidence 0.32 Published 2009 Journal Pain Section Body Doc Link PMC2702711 Disease Relevance 0.24 Pain Relevance 0.78
Looking at infiltrating macrophages as another main arm of the innate immune system that has a stronger influence in the early times of life [26-28] revealed a significant increase of CD163+ macrophages in grafts of NK-cell-deficient recipients (p<0.01; Figure 4A,B).
Positive_regulation (increase) of CD163 in immune system
4) Confidence 0.29 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2956665 Disease Relevance 0 Pain Relevance 0

General Comments

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