INT154376

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Context Info
Confidence 0.24
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.21
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gars) ligase activity (Gars) cytoplasm (Gars)
Anatomy Link Frequency
neurons 1
Gars (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 13 98.56 Very High Very High Very High
Analgesic 2 97.48 Very High Very High Very High
Hippocampus 11 94.88 High High
Cannabinoid 10 92.52 High High
GABAergic 3 84.60 Quite High
spinal dorsal horn 17 78.48 Quite High
agonist 2 76.76 Quite High
Endocannabinoid 1 72.80 Quite High
Potency 1 69.52 Quite High
IPN 2 67.76 Quite High
Disease Link Frequency Relevance Heat
Nociception 4 73.68 Quite High
Inflammatory Pain 2 67.76 Quite High
Pain 6 67.44 Quite High
Premenstrual Syndrome 6 41.32 Quite Low
Epilepsy 2 5.00 Very Low Very Low Very Low
Anxiety Disorder 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low
Affective Disorder 1 5.00 Very Low Very Low Very Low
Convulsion 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In hippocampal (HIP) neurons, GlyRs are thought to be primarily the homopentamer of ?
Positive_regulation (thought) of GlyRs in neurons
1) Confidence 0.24 Published 2009 Journal Mol Pain Section Body Doc Link PMC2651124 Disease Relevance 0.14 Pain Relevance 0.42
Recombinant alpha1 and alpha1beta GlyRs were potentiated by anandamide and HU-210 at submicromolar concentrations, whereas WIN55,212-2 had no effect and HU-308 produced only weak inhibition.
Positive_regulation (potentiated) of GlyRs
2) Confidence 0.05 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18755158 Disease Relevance 0.07 Pain Relevance 0.69

General Comments

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