INT154388

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Context Info
Confidence 0.67
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 7.75
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (DEFB4A)
Anatomy Link Frequency
epithelial cells 2
keratinocytes 2
DEFB4A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 126 99.84 Very High Very High Very High
psoriasis 250 97.64 Very High Very High Very High
rheumatoid arthritis 50 86.52 High High
Inflammation 78 85.76 High High
Arthritis 5 62.32 Quite High
spastic colon 4 50.00 Quite Low
chemokine 7 27.44 Quite Low
Inflammatory response 2 17.00 Low Low
cINOD 5 5.00 Very Low Very Low Very Low
Crohn's disease 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Eczema 95 100.00 Very High Very High Very High
Hemophilus Infection 80 98.44 Very High Very High Very High
Disease 191 97.84 Very High Very High Very High
Psoriasis 345 97.64 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

2 88.92 High High
Functional Bowel Disorder 4 88.72 High High
Diarrhoea 4 87.24 High High
Infection 17 86.80 High High
Rheumatoid Arthritis 50 86.52 High High
INFLAMMATION 81 85.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: The expressions of HBD-2 and TNF-at are significantly increased in UC, but are not correlated with IBS-D and the severity of clinical symptoms of UC patients.


Positive_regulation (increased) of Gene_expression (expressions) of HBD-2
1) Confidence 0.67 Published 2008 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 18756966 Disease Relevance 0.12 Pain Relevance 0
We could indeed show that Th2 cytokines do not induce hBD-2 expression in cultured keratinocytes [18] and that Th2 cytokines repress the Th1 induced expression (not shown here), as was previously shown for hBD-3 [43].
Neg (not) Positive_regulation (induce) of Gene_expression (expression) of hBD-2 in keratinocytes associated with cytokine
2) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 1.12 Pain Relevance 0.48
-defensin 2 (DEFB4) promoter construct was transfected into HMEEC followed by treatment with NTHi lysate and IL-1?
Positive_regulation (transfected) of Gene_expression (transfected) of DEFB4 associated with hemophilus infection
3) Confidence 0.49 Published 2006 Journal BMC Infect Dis Section Body Doc Link PMC1368979 Disease Relevance 0.97 Pain Relevance 0
METHODS: Immunohistochemistry was conducted on the biopsy samples of colonic mucosa from 30 UC patients, 20 IBS-D patients, and 10 normal persons to measure the expression of HBD-2 and TNF-alpha.
Positive_regulation (measure) of Gene_expression (expression) of HBD-2
4) Confidence 0.48 Published 2008 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 18756966 Disease Relevance 0.18 Pain Relevance 0
As previously reported [10], hBD-2 protein is expressed at low to undetectable levels (immunohistochemistry) in lesional atopic dermatitis, despite strong induction at the mRNA level.
Positive_regulation (induction) of Gene_expression (expressed) of hBD-2 protein associated with eczema
5) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 1.72 Pain Relevance 0.39
Although our findings indicate that uninduced hBD-2 production is subject to gene dosage effects, the high systemic serum levels in psoriasis patients are caused by disease activity itself.
Positive_regulation (uninduced) of Gene_expression (production) of hBD-2 associated with psoriasis and disease
6) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 0.77 Pain Relevance 0.20
Although our findings indicate that uninduced hBD-2 production is subject to gene dosage effects, the high systemic serum levels in psoriasis patients are caused by disease activity itself.
Positive_regulation (subject) of Gene_expression (production) of hBD-2 associated with psoriasis and disease
7) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 0.83 Pain Relevance 0.20
In sera from 8 patients with moderate to severe atopic dermatitis we found that, although serum hBD-2 levels were significantly higher than in control sera (t-test, p<10?
Positive_regulation (serum) of Gene_expression (levels) of hBD-2 associated with eczema
8) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 1.72 Pain Relevance 0.36
-defensin family appear to be expressed by most epithelial cells of the small and large intestine, HBD-1 being expressed constitutively, while HBD-2 synthesis is induced by activation of the transcriptional factor NF?
Positive_regulation (induced) of Gene_expression (synthesis) of HBD-2 in epithelial cells
9) Confidence 0.16 Published 2010 Journal Eplasty Section Body Doc Link PMC2803769 Disease Relevance 0.17 Pain Relevance 0.08

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