INT154448

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.11
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (FOSB) DNA binding (FOSB) transcription factor binding (FOSB)
Anatomy Link Frequency
striatum 1
FOSB (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 55 97.80 Very High Very High Very High
metalloproteinase 2 63.44 Quite High
cytokine 28 53.52 Quite High
Inflammatory response 8 40.16 Quite Low
Enkephalin 2 25.00 Low Low
Arthritis 10 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
chemokine 5 5.00 Very Low Very Low Very Low
Inflammatory marker 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Gauchers Disease 86 99.74 Very High Very High Very High
INFLAMMATION 69 97.80 Very High Very High Very High
Parkinson's Disease 3 95.88 Very High Very High Very High
Dyskinesias 9 95.20 Very High Very High Very High
Atherosclerosis 44 94.60 High High
Obesity 9 91.64 High High
Disorder Of Lipid Metabolism 6 83.32 Quite High
Repression 2 82.60 Quite High
Adhesions 7 81.44 Quite High
Apoptosis 8 78.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In situ hybridization histochemistry and immunohistochemistry analysis of the striatum also showed a reduction in the levels of prodynorphin mRNA and FosB/DeltaFosB-immunopositive cells in creatine-supplemented diet group, an effect that was dependant on the development of AIMs.
Negative_regulation (reduction) of FosB in striatum associated with dyskinesias
1) Confidence 0.41 Published 2009 Journal Behav. Brain Res. Section Abstract Doc Link 18762218 Disease Relevance 0.75 Pain Relevance 0
Via negative regulation of nuclear factor-kappa B and activator protein-1 signaling pathways, PPAR alpha inhibits expression of inflammatory genes, such as interleukin-6, cyclooxygenase-2, and endothelin-1.
Negative_regulation (regulation) of activator protein-1 associated with inflammation
2) Confidence 0.02 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.84 Pain Relevance 0.16
Rare variant forms of Gaucher disease result from deficiency of the sphingolipid activator protein, saposin C.3 Latterly, inherited defects in a recently discovered molecule, LIMP-2, have been associated with an usual phenotype with ?
Negative_regulation (deficiency) of activator protein associated with gauchers disease
3) Confidence 0.02 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC3010821 Disease Relevance 0.52 Pain Relevance 0

General Comments

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