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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.92

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enzyme binding (Esr1) DNA binding (Esr1) protein complex (Esr1)
cytoplasm (Esr1) lipid binding (Esr1) nucleus (Esr1)
Anatomy Link Frequency
hypothalamus 2
Esr1 (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 11 99.60 Very High Very High Very High
Dopamine 1 85.76 High High
Serotonin 1 85.36 High High
Neurotransmitter 1 84.96 Quite High
monoamine 1 84.24 Quite High
Neuropeptide 1 78.88 Quite High
sSRI 1 74.40 Quite High


Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that fluoxetine also significantly reduced the expression of estrogen receptor (ER)beta1 mRNA by 4-fold in both the hypothalamus and the telencephalon and ERalpha mRNA by 1.7-fold in the telencephalon.
Negative_regulation (reduced) of Transcription (expression) of estrogen receptor in hypothalamus associated with fluoxetine
1) Confidence 0.05 Published 2008 Journal Physiol. Genomics Section Abstract Doc Link 18765858 Disease Relevance 0 Pain Relevance 0.92

General Comments

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