INT154465

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Esr1) DNA binding (Esr1) protein complex (Esr1)
cytoplasm (Esr1) lipid binding (Esr1) nucleus (Esr1)
Anatomy Link Frequency
hypothalamus 2
Esr1 (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 11 99.60 Very High Very High Very High
Dopamine 1 85.76 High High
Serotonin 1 85.36 High High
Neurotransmitter 1 84.96 Quite High
monoamine 1 84.24 Quite High
Neuropeptide 1 78.88 Quite High
sSRI 1 74.40 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that fluoxetine also significantly reduced the expression of estrogen receptor (ER)beta1 mRNA by 4-fold in both the hypothalamus and the telencephalon and ERalpha mRNA by 1.7-fold in the telencephalon.
Negative_regulation (reduced) of Transcription (expression) of estrogen receptor in hypothalamus associated with fluoxetine
1) Confidence 0.05 Published 2008 Journal Physiol. Genomics Section Abstract Doc Link 18765858 Disease Relevance 0 Pain Relevance 0.92

General Comments

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