INT154468

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Context Info
Confidence 0.29
First Reported 2004
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.14
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ESR1) enzyme binding (ESR1) DNA binding (ESR1)
protein complex (ESR1) cytoplasm (ESR1) signal transduction (ESR1)
Anatomy Link Frequency
hypothalamus 2
ESR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 11 99.60 Very High Very High Very High
Dopamine 2 85.76 High High
Serotonin 1 85.36 High High
Neurotransmitter 1 84.96 Quite High
monoamine 1 84.24 Quite High
nud 1 80.40 Quite High
Neuropeptide 1 79.20 Quite High
sSRI 1 74.40 Quite High
Codeine 2 5.00 Very Low Very Low Very Low
beta blocker 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 95 99.68 Very High Very High Very High
Breast Cancer 42 87.60 High High
Dyspepsia 1 80.40 Quite High
Vomiting 5 79.84 Quite High
Disease 49 72.48 Quite High
Chronic Myeloid Leukemia 1 65.60 Quite High
Volume Depletion And Dehydration 1 48.08 Quite Low
Appetite Loss 1 47.04 Quite Low
Diarrhoea 3 46.00 Quite Low
Targeted Disruption 4 33.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both of these epigenetic modifications can repress ER transcription and have been implicated in endocrine resistance [61].
Negative_regulation (repress) of Transcription (transcription) of ER
1) Confidence 0.29 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2242654 Disease Relevance 0.58 Pain Relevance 0.04
In the case of ER, the reason is that the protein stability but not the mRNA expression determines the levels of the ER in the tumour cells and thus the ER status of the tumors [130].
Spec (determines) Negative_regulation (determines) of Transcription (expression) of ER associated with cancer
2) Confidence 0.29 Published 2008 Journal Eur J Clin Pharmacol Section Body Doc Link PMC2235910 Disease Relevance 0.33 Pain Relevance 0
We found that fluoxetine also significantly reduced the expression of estrogen receptor (ER)beta1 mRNA by 4-fold in both the hypothalamus and the telencephalon and ERalpha mRNA by 1.7-fold in the telencephalon.
Negative_regulation (reduced) of Transcription (expression) of ER in hypothalamus associated with fluoxetine
3) Confidence 0.06 Published 2008 Journal Physiol. Genomics Section Abstract Doc Link 18765858 Disease Relevance 0 Pain Relevance 0.92
-estradiol to parous rats, while unequivocally causing a significant stimulation of mammary development and a large increase in mammary tumorigenesis, will cause a significant reduction in mRNA levels of ER-?
Negative_regulation (reduction) of Transcription (levels) of ER
4) Confidence 0.02 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468665 Disease Relevance 0.23 Pain Relevance 0

General Comments

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