INT154494

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Context Info
Confidence 0.72
First Reported 2004
Last Reported 2008
Negated 0
Speculated 2
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 0.99
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (AKR1C1) oxidoreductase activity (AKR1C1) cytoplasm (AKR1C1)
Anatomy Link Frequency
myometrium 4
mammary gland 1
AKR1C1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 4 82.08 Quite High
antagonist 1 47.24 Quite Low
ischemia 4 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
medulla 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metastasis 55 94.96 High High
Prostate Cancer 55 84.20 Quite High
Dysmenorrhea 4 82.08 Quite High
Cancer 104 56.68 Quite High
Adhesions 14 45.20 Quite Low
Disease 5 37.76 Quite Low
Breast Cancer 24 35.56 Quite Low
Carcinoma 8 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 4 5.00 Very Low Very Low Very Low
Aggression 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quantitative real-time reverse-transcriptase polymerase chain reaction was used to compare relative mRNA expression of AKR1C1 and SRD5A1 in the myometrium and chorioamniotic membranes from 20 subjects during three different states of labor: not in labor ( N = 10), spontaneous labor ( N = 5), or induced labor ( N = 5).
Transcription (expression) of AKR1C1 in myometrium
1) Confidence 0.72 Published 2008 Journal Am J Perinatol Section Abstract Doc Link 18770491 Disease Relevance 0.08 Pain Relevance 0.08
We sought to determine relative mRNA expression of AKR1C1 and SRD5A1, which respectively encode for the key progesterone metabolizing enzymes, 20alpha-hydroxysteroid dehydrogenase and 5alpha-reductase type 1, in the myometrium and chorioamniotic membranes during human spontaneous or induced labor and nonlabor.
Spec (determine) Transcription (expression) of AKR1C1 in myometrium
2) Confidence 0.72 Published 2008 Journal Am J Perinatol Section Abstract Doc Link 18770491 Disease Relevance 0.05 Pain Relevance 0.05
AKR1C1 and SRD5A1 messenger RNA expression at term in the human myometrium and chorioamniotic membranes.
Transcription (expression) of AKR1C1 in myometrium
3) Confidence 0.53 Published 2008 Journal Am J Perinatol Section Title Doc Link 18770491 Disease Relevance 0.07 Pain Relevance 0.07
We sought to determine relative mRNA expression of AKR1C1 and SRD5A1, which respectively encode for the key progesterone metabolizing enzymes, 20alpha-hydroxysteroid dehydrogenase and 5alpha-reductase type 1, in the myometrium and chorioamniotic membranes during human spontaneous or induced labor and nonlabor.
Spec (determine) Transcription (expression) of 20alpha-hydroxysteroid dehydrogenase in myometrium
4) Confidence 0.52 Published 2008 Journal Am J Perinatol Section Abstract Doc Link 18770491 Disease Relevance 0.06 Pain Relevance 0.06
The expression of AKR1C1, AKR1C2 and AKR1C3 mRNAs has been detected in human mammary gland [24,27-29].
Transcription (expression) of AKR1C1 in mammary gland
5) Confidence 0.51 Published 2004 Journal BMC Cancer Section Body Doc Link PMC459223 Disease Relevance 0.06 Pain Relevance 0
However, in contrast to their findings, transcripts for AKR1C3, SRD5A1, HSD3B2, AKR1C2, AKR1C1 are not consistently upregulated in the metastatic samples in our study.
Transcription (transcripts) of AKR1C1
6) Confidence 0.38 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1865555 Disease Relevance 0.67 Pain Relevance 0

General Comments

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