INT154497

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Context Info
Confidence 0.04
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.91
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptprq)
Anatomy Link Frequency
neurons 1
soma 1
Ptprq (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Periaqueductal grey 10 99.84 Very High Very High Very High
Pyramidal cell 25 89.68 High High
antiepileptic Drug 7 87.40 High High
Dopamine 103 86.72 High High
Migraine 4 80.32 Quite High
Action potential 16 71.48 Quite High
Lamotrigine 3 71.36 Quite High
Somatosensory cortex 3 60.88 Quite High
Potency 1 55.20 Quite High
imagery 7 54.96 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 11 99.84 Very High Very High Very High
Headache 4 80.32 Quite High
Decapitation 2 55.60 Quite High
Diabetes Mellitus 6 25.00 Low Low
Amphetamine Dependence 1 25.00 Low Low
Disseminated Intravascular Coagulation 1 16.72 Low Low
Drug Dependence 2 5.00 Very Low Very Low Very Low
Opiate Addiction 1 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low
Congenital Anomalies 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro studies suggest that hypoinsulinemia may regulate the actions of AMPH by inhibiting the insulin downstream effectors phosphotidylinositol 3-kinase (PI3K) and protein kinase B (PKB, or Akt), which we have previously shown are able to fine-tune DAT cell-surface expression.
Gene_expression (expression) of phosphotidylinositol 3-kinase
1) Confidence 0.04 Published 2007 Journal PLoS Biology Section Abstract Doc Link PMC2020502 Disease Relevance 0 Pain Relevance 0.27
We show that five Ca2+ channel sub-types (L-, N-, R- and P/Q-type) are expressed in the soma of these neurones.
Gene_expression (expressed) of Q-type in soma
2) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659773 Disease Relevance 0.06 Pain Relevance 0.21
In particular, we found that P- and Q-type HVA Ca(2+) channels were more expressed in PAG neurons than in cortical cells, whereas L- and R-type HVA Ca(2+) channels showed an opposite distribution.
Gene_expression (expressed) of Q-type in neurons associated with periaqueductal grey
3) Confidence 0.00 Published 2008 Journal Cephalalgia Section Abstract Doc Link 18771493 Disease Relevance 0.86 Pain Relevance 0.83

General Comments

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