INT15450

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.34
First Reported 1987
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 4.53
Pain Relevance 4.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpe) extracellular space (Cpe) extracellular region (Cpe)
Golgi apparatus (Cpe)
Anatomy Link Frequency
striatum 4
fat 2
brain 2
spleens 2
Cpe (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 35 100.00 Very High Very High Very High
opiate 8 100.00 Very High Very High Very High
Dopamine 12 98.88 Very High Very High Very High
Dynorphin 3 96.24 Very High Very High Very High
medulla 1 94.60 High High
agonist 3 92.44 High High
narcan 10 91.64 High High
antagonist 8 91.28 High High
dopamine receptor 6 88.72 High High
Nucleus accumbens 1 86.56 High High
Disease Link Frequency Relevance Heat
Anxiety Disorder 7 99.98 Very High Very High Very High
Targeted Disruption 24 99.52 Very High Very High Very High
Obesity 20 99.52 Very High Very High Very High
Osteogenic Sarcomas 64 99.48 Very High Very High Very High
Hyperplasia 1 95.84 Very High Very High Very High
Sprains And Strains 6 90.72 High High
Diabetes Mellitus 3 89.32 High High
Catalepsy 4 85.12 High High
Cancer 76 83.04 Quite High
Alcohol Addiction 1 78.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neurochemical analysis of C57 mice, following high voluntary ethanol consumption (approximately 17 g/kg/day), revealed markedly higher enkephalin gene expression in the striatum and mid brain compared to ethanol-naive animals.
Positive_regulation (higher) of Gene_expression (expression) of enkephalin in brain associated with enkephalin
1) Confidence 0.34 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8884235 Disease Relevance 0.24 Pain Relevance 0.65
Intraperitoneal injection of Leu-enkephalin (LENK, 10 or 7.5 mg/kg) induced bidirectional modulation of natural cytotoxic activities in spleens of CBA mice (suppression followed by enhancement).
Positive_regulation (induced) of Gene_expression (injection) of Leu-enkephalin in spleens associated with enkephalin
2) Confidence 0.31 Published 1992 Journal Life Sci. Section Abstract Doc Link 1728722 Disease Relevance 0 Pain Relevance 0.36
These findings were supported by findings of increased dermal met-enkephalin expression in cholestatic mice.
Positive_regulation (increased) of Gene_expression (expression) of met-enkephalin
3) Confidence 0.16 Published 2006 Journal J. Hepatol. Section Body Doc Link 16466825 Disease Relevance 0.07 Pain Relevance 0
The expression of enkephalin mRNA in the striatum is increased in the D2R knockout mice.
Positive_regulation (increased) of Gene_expression (expression) of enkephalin mRNA in striatum associated with targeted disruption and enkephalin
4) Confidence 0.11 Published 1999 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 10803208 Disease Relevance 0.90 Pain Relevance 0.45
The expression of enkephalin mRNA in the striatum is increased in the mutant mice, but not that of dynorphin and substance P.
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of enkephalin in striatum
5) Confidence 0.10 Published 1996 Journal Genes Cells Section Body Doc Link 9140068 Disease Relevance 0 Pain Relevance 0
Naïve wild-type and knockout mice were also examined for enkephalin and dynorphin mRNA expression by in situ hybridization and for mu-opiate receptor by ligand binding autoradiography to check for possible opiate receptor changes induced by A2A receptor inactivation.
Spec (examined) Positive_regulation (examined) of Spec (examined) Gene_expression (expression) of enkephalin
6) Confidence 0.08 Published 2006 Journal Psychopharmacology (Berl.) Section Body Doc Link 16470403 Disease Relevance 0.08 Pain Relevance 0
Brief exposure to predator odor and resultant anxiety enhances mesocorticolimbic activity and enkephalin expression in CD-1 mice.
Positive_regulation (enhances) of Gene_expression (expression) of enkephalin associated with anxiety disorder and enkephalin
7) Confidence 0.08 Published 2004 Journal Eur. J. Neurosci. Section Title Doc Link 15525282 Disease Relevance 0.34 Pain Relevance 0.89
The cataleptic response and the increase of enkephalin mRNA expression induced by haloperidol can also be suppressed by administration of retinoid ligands 9-cis retinoic acid and docosahexaenoic acid.
Positive_regulation (increase) of Gene_expression (expression) of enkephalin mRNA associated with enkephalin
8) Confidence 0.08 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 14603264 Disease Relevance 0.39 Pain Relevance 0.55
Selective stimulation of mu- and delta-opiate receptors using the enkephalin analogues Tyr-D-Ala-Gly-MePhe-NH(CH2)2OH (1 mg/kg, intraperitoneally) and Tyr-D-Ala-Gly-Phe-D-Leu (10 mg/kg intraperitoneally) respectively, rapidly and transiently increased glucose and insulin concentrations in lean and ob/ob mice.
Positive_regulation (stimulation) of Gene_expression (using) of enkephalin associated with obesity, enkephalin and opiate
9) Confidence 0.07 Published 1987 Journal Diabetologia Section Abstract Doc Link 3032718 Disease Relevance 0.76 Pain Relevance 0.67
The cataleptic response and the increase of enkephalin mRNA expression induced by haloperidol can also be suppressed by administration of retinoid ligands 9-cis retinoic acid and docosahexaenoic acid.
Positive_regulation (induced) of Gene_expression (expression) of enkephalin mRNA associated with enkephalin
10) Confidence 0.05 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 14603264 Disease Relevance 0.39 Pain Relevance 0.55
These cells were also negative for various striatal markers such as Ebf1 or enkephalin mRNAs and calbindin, DARPP32 and dopamine 2 receptor, suggesting that they are unable to differentiate (Colombo et al., 2007).
Positive_regulation (negative) of Gene_expression (mRNAs) of enkephalin associated with dopamine and enkephalin
11) Confidence 0.04 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2841486 Disease Relevance 0 Pain Relevance 0.18
Results showed that osteosarcoma growth was significantly increased by fat injection whereas fat alone produced only small and stable volumes at injection sites in naive mice.
Positive_regulation (increased) of Gene_expression (injection) of fat in fat associated with osteogenic sarcomas
12) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882323 Disease Relevance 1.37 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox